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This nanoprobe,\n                    <jats:bold>HSDPP<\/jats:bold>\n                    , could be effectively activated by H\n                    <jats:sub>2<\/jats:sub>\n                    S to form H\u2010type aggregates with green emission; subsequently, the aggregates could bind to mtDNA to form monomers and the emIssion color switched from green to deep\u2010red. We exploited\n                    <jats:bold>HSDPP<\/jats:bold>\n                    to image exogenous and endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S in living cells. Of note, for the first time, this novel nanoprobe with an optimal partition coefficient value (LogP=1.269) was successfully applied for tracking the endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S upregulation stimulated by cystathionase activator\n                    <jats:italic>S<\/jats:italic>\n                    \u2010adenosyl\u2010\n                    <jats:italic>L<\/jats:italic>\n                    \u2010methionine (SAM) in mice brains. Finally, our work provides an invaluable chemical tool for probing endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S upregulation in\u2005vitro\/vivo and, importantly, affords a prospective design strategy for developing switchable chemosensors to unveil the relationship between biomolecules and DNA in mitochondria in many promising areas.\n                  <\/jats:p>","DOI":"10.1002\/asia.202000964","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T07:17:17Z","timestamp":1600672637000},"page":"3551-3557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An Activatable and Switchable Nanoaggregate Probe for Detecting H\n                    <sub>2<\/sub>\n                    S and Its Application in Mice Brains"],"prefix":"10.1002","volume":"15","author":[{"given":"Ya\u2010Lin","family":"Qi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University  Nanjing 210023 P. 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