{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:42:57Z","timestamp":1789706577139,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030107"],"award-info":[{"award-number":["82030107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21702046"],"award-info":[{"award-number":["21702046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018\u2005M632757"],"award-info":[{"award-number":["2018\u2005M632757"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) is recognized as an endogenous gaseous signaling agent in many biological activities. Lysosomes are the main metabolic site and play a pivotal role in cells. Herein, we designed and synthesized two new fluorescent probes\n                    <jats:bold>BDP\u2010DNBS<\/jats:bold>\n                    and\n                    <jats:bold>BDP\u2010DNP<\/jats:bold>\n                    with a BODIPY core to distinguish H\n                    <jats:sub>2<\/jats:sub>\n                    S. The sensing mechanism is based on the inhibition\u2010recovery of the photo\u2010induced electron transfer (PET) process. Through comparing the responsive behaviors of the two probes toward H\n                    <jats:sub>2<\/jats:sub>\n                    S,\n                    <jats:bold>BDP\u2010DNBS<\/jats:bold>\n                    showed a fast response time (60\u2005s), low limit of detection (LOD, 51\u2005nM), high sensitivity and selectivity. Moreover, the reaction mechanism was demonstrated by mass spectrometry and fluorescence off\u2010on mechanism was proved by density functional theory (DFT). Significantly, confocal fluorescence imaging indicated that\n                    <jats:bold>BDP\u2010DNBS<\/jats:bold>\n                    was successfully used to visualize H\n                    <jats:sub>2<\/jats:sub>\n                    S in lysosomes in living HeLa cells.\n                  <\/jats:p>","DOI":"10.1002\/asia.202100041","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T23:16:07Z","timestamp":1614726967000},"page":"850-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["BODIPY\u2010based Fluorescent Probe for Fast Detection of Hydrogen Sulfide and Lysosome\u2010targeting Applications in Living Cells"],"prefix":"10.1002","volume":"16","author":[{"given":"Jinlei","family":"Yue","sequence":"first","affiliation":[{"name":"Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and Engineering Henan University  Kaifeng 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfang","family":"Tao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and Engineering Henan University  Kaifeng 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8333-6508","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and Engineering Henan University  Kaifeng 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and Engineering Henan University  Kaifeng 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and Engineering Henan University  Kaifeng 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and Engineering Henan University  Kaifeng 475004 P. R. China"},{"name":"School of Pharmacy Institutes of Integrative Medicine Fudan University  Shanghai 201203 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja303261d"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol400973v"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvr018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.041002.131047"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.08.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.517995"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90566.2008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3517"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709010104"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4712fje"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6270fje"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705891104"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1082"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100505"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CC37329G"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.10847"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1162667"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20817"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.745"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja308967u"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.584391"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4109(200012)12:18<1453::AID-ELAN1453>3.0.CO;2-Z"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(98)00882-6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(00)80915-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0347336"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC03312D"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA11870G"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC03707G"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC09771H"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC03516J"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC02323B"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC04093H"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c06533"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b04009"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c01623"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904470"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00298A"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja404004v"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3sc50369k"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201207701"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2018.10.086"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC03312D"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b01373"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2015.07.026"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA06952E"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.150631"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2017.10.133"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b02459"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC05539J"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.8b01101"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.06.021"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr078381n"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2018.01.016"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201902301"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2018.11.066"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201901709"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000313"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2020.109089"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2018.03.015"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.3.599"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b02021"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.05.005"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2017.10.133"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200702271"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202100041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/asia.202100041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202100041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:37:07Z","timestamp":1759923427000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.202100041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,10]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/asia.202100041"],"URL":"https:\/\/doi.org\/10.1002\/asia.202100041","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,10]]},"assertion":[{"value":"2021-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}