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Here, a fluorescent probe <jats:bold>TC426<\/jats:bold> with aggregation\u2010induced emission (AIE) characteristics is reported as a sensitive and specific probe for HSA. This probe is non\u2010emissive in aqueous solution, meanwhile it shows bright fluorescence upon interacting with HSA, which makes it applicable in detecting HSA with a high signal to noise ratio. Besides, the fluorescence of <jats:bold>TC426<\/jats:bold> exhibits a high linear correlation with the concentration of albumin in the range of microalbumin (20\u2013200\u2005mg\/L), which has a significant importance for the early diagnosis of glomerulus related diseases. Compared with previously reported HSA probes <jats:bold>TPE\u20104TA<\/jats:bold> and <jats:bold>BSPOTPE<\/jats:bold>, <jats:bold>TC426<\/jats:bold> shows comparable anti\u2010interference ability towards creatinine and other major components in urine but is excited by a longer excitation wavelength at the visible light range. Finally, with the established assay, <jats:bold>TC426<\/jats:bold> shows excellent performance in detecting HSA in real human urine, indicating its great potential in practical urinalysis.<\/jats:p>","DOI":"10.1002\/asia.202100180","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T23:05:09Z","timestamp":1616540709000},"page":"1245-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Detection of Urinary Albumin Using a \u201cTurn\u2010on\u201d Fluorescent Probe with Aggregation\u2010Induced Emission Characteristics"],"prefix":"10.1002","volume":"16","author":[{"given":"Qi","family":"Hu","sequence":"first","affiliation":[{"name":"Medical Device Research Institute College of Science and Engineering Flinders University  South Australia 5042 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bicheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics La Trobe Institute for Molecular Science La Trobe University  Victoria 3086 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Cin","family":"Owyong","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics La Trobe Institute for Molecular Science La Trobe University  Victoria 3086 Australia"},{"name":"ARC Centre of Excellence in Exciton Science School of Chemistry Bio21 Institute The University of Melbourne  Victoria 3010 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Prashanth","sequence":"additional","affiliation":[{"name":"Medical Device Research Institute College of Science and Engineering Flinders University  South Australia 5042 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Device Research Institute College of Science and Engineering Flinders University  South Australia 5042 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Device Research Institute College of Science and Engineering Flinders University  South Australia 5042 Australia"},{"name":"Australia-China Joint Research Centre for Personal Health Technologies Flinders University  South Australia 5042 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallace W. 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