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Based on clinical findings, acetone concentration in human breath is correlated with many diseases such as asthma, halitosis, lung cancer, and diabetes. Thus, its investigation can become a new approach for health monitoring. Better management at the early stages of such diseases has the potential not only to reduce deaths associated with the disease but also to reduce medical costs. ZnO\u2212based sensors show great potential for acetone gas due to their high chemical stability, simple synthesis process, and low cost. The findings suggested that the acetone sensing performance of such sensors can be significantly improved by manipulating the microstructure (surface area, porosity, etc.), composition, and morphology of ZnO nanomaterials. This article provides a comprehensive review of the state\u2010of\u2010the\u2010art research activities, published during the last five years (2016 to 2020), related to acetone gas sensing using nanostructured ZnO (nanowires, nanoparticles, nanorods, thin films, etc). It focuses on different types of nanostructured ZnO\u2010based acetone gas sensors. Furthermore, several factors such as relative humidity, acetone concentrations, and operating temperature that affects the acetone gas sensing properties\u2010 sensitivity, long\u2010term stability, selectivity as well as response and recovery time are discussed in this review. We hope that this work will inspire the development of high\u2010performance acetone gas sensors using nanostructured materials.<\/jats:p>","DOI":"10.1002\/asia.202100303","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T12:15:34Z","timestamp":1620648934000},"page":"1519-1538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Zinc Oxide\u2010Based Acetone Gas Sensors for Breath Analysis: A Review"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1286-3415","authenticated-orcid":false,"given":"Qasem A.","family":"Drmosh","sequence":"first","affiliation":[{"name":"Center of Excellence in Nanotechnology King Fahd University of Petroleum &amp; Minerals  Dhahran 31261 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Olanrewaju Alade","sequence":"additional","affiliation":[{"name":"Department of Physics King Fahd University of Petroleum &amp; Minerals  Dhahran 31261 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Qamar","sequence":"additional","affiliation":[{"name":"Center of Excellence in Nanotechnology King Fahd University of Petroleum &amp; Minerals  Dhahran 31261 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh","family":"Akbar","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Department The Ohio State University  Columbus OH, 43212 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"e_1_2_17_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB01335J"},{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adom.201800677"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/8\/1\/014001"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.8b00937"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.02.012"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.02.002"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2019.116213"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/s19020233"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7155\/5\/3\/037110"},{"key":"e_1_2_17_10_1","unstructured":"and P.\u2005I.\u2005G.\u2005J. 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