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Soybean pod shell peroxidase (SPSP) is a peroxidase extracted from soybean pods shells which are one of the most abundant natural resources in the world. In the production of chiral sulfoxides catalyzed by SPSP, it is very important to establish the reaction kinetic model and explore the reaction mechanism for the development of the process, however, there is no report on the establishment of the model. Asymmetric sulfoxidation reactions catalyzed by SPSP in water\u2010in\u2010oil microemulsions were carried out, and the King\u2010Altman approach was used to establish a kinetic model. A yield of 91% and e.e. value of 96% for esomeprazole were obtained at the activity of SPSP of 3200\u2005U\u2009ml<jats:sup>\u22121<\/jats:sup> and 50\u2009\u00b0C for 5\u2005h. The mechanism with a two\u2010electron reduction of SPSP\u2010I is accompanied with a single\u2010electron transfer to SPSP\u2010I and nonenzymatic reactions, indicating that three concomitant sub\u2010mechanisms contribute to the asymmetric oxidation involving five enzymatic and two nonenzymatic reactions, which can represent the asymmetric sulfoxidation of organic sulfides to form enantiopure sulfoxides. With 5.44% of the average relative deviation, a kinetic model fitting experimental data was developed. The enzymatic reactions may follow ping\u2010pong mechanism with substrate inhibition of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and product inhibition of esomeprazole, while nonenzymatic reactions follow a power law. Those results indicate that SPSP with a lower cost and higher thermal stability may be used as an effective substitute for horseradish peroxidase.<\/jats:p>","DOI":"10.1002\/asia.202100467","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T03:23:50Z","timestamp":1623641030000},"page":"2075-2086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Asymmetric Sulfoxidation of Thioether Catalyzed by Soybean Pod Shell Peroxidase to Form Enantiopure Sulfoxide in Water\u2010in\u2010Oil Microemulsions: A Kinetic Model"],"prefix":"10.1002","volume":"16","author":[{"given":"Huiling","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory Base for Eco-Chemical Engineering in College of Chemical Engineering Qingdao University of Science and Technology Mailbox 70  53 Zhengzhou Road Qingdao 266042 P. R. 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