{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:47:41Z","timestamp":1793148461402,"version":"4.5.0"},"reference-count":101,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22022707"],"award-info":[{"award-number":["22022707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177142"],"award-info":[{"award-number":["22177142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21837006"],"award-info":[{"award-number":["21837006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metal complexes have shown great potential in cancer immunotherapy. This review briefly introduces the basic concepts and strategies of cancer immunotherapy and summarizes the recent discoveries on the immune effects of traditional platinum\u2010based anticancer compounds. In addition, we also outline the latest research progresses on metal complexes for cancer immunotherapy focusing on platinum, ruthenium, iridium, rhenium and copper complexes. Finally, the research perspectives and unsolved problems on the applications of metallo\u2010anticancer agents in cancer immunotherapy are purposed.<\/jats:p>","DOI":"10.1002\/asia.202200270","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T22:44:16Z","timestamp":1649889856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Rising Interest in the Development of Metal Complexes in Cancer Immunotherapy"],"prefix":"10.1002","volume":"17","author":[{"given":"Zhi\u2010Yuan","family":"Li","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University  Guangzhou 510006 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Hua","family":"Shen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University  Guangzhou 510006 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-1154","authenticated-orcid":false,"given":"Zong\u2010Wan","family":"Mao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University  Guangzhou 510006 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-8367","authenticated-orcid":false,"given":"Cai\u2010Ping","family":"Tan","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University  Guangzhou 510006 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26113382"},{"key":"e_1_2_7_3_1","unstructured":"\u00a0"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007630"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092637"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.342.6165.1432"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-06751-0"},{"key":"e_1_2_7_8_1","first-page":"589","volume":"59","author":"Rosenberg B.","year":"1975","journal-title":"Cancer Chemother. Rep."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2019.118987"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-1-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.6-suppl_2-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8DT00838H"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3DT52524D"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01689"},{"key":"e_1_2_7_16_1","first-page":"1548","volume":"30","author":"He L.","year":"2018","journal-title":"Prog. Chem."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27020539"},{"key":"e_1_2_7_18_1","unstructured":"\u00a0"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201905171"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201600908"},{"key":"e_1_2_7_21_1","unstructured":"\u00a0"},{"key":"e_1_2_7_22_2","first-page":"1573","volume":"30","author":"Sun Y. W.","year":"2018","journal-title":"Prog. Chem."},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1360\/SSC-2019-0040"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00396"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2018-0029"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.693709"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00148"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802228"},{"key":"e_1_2_7_29_1","unstructured":"\u00a0"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-020-3179-9"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0QM00323A"},{"key":"e_1_2_7_32_1","first-page":"454","volume":"26","author":"Du N. W.","year":"2019","journal-title":"Chin. J. Cancer Biother."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10290"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.11.006"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2007.08.004"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00398"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2017.28999.old"},{"key":"e_1_2_7_38_1","unstructured":"\u00a0"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83871"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0306-5"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202002104"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4060"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32446"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407190-2.00007-1"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43656"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2236"},{"key":"e_1_2_7_47_1","first-page":"130","volume":"16","author":"Feng Q. M.","year":"2009","journal-title":"Chin. J. Cancer Biother."},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032542"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.06.021"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-100008"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00417D"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00308-y"},{"key":"e_1_2_7_53_1","unstructured":"\u00a0"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.356"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm100953c"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-018-2979-1"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201500934"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-017-1459-y"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.01.005"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.077321"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111628"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008604"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00221"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC06563F"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4360"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01860"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00781"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC02071J"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113873109"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.02.063"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011273"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0825-4"},{"key":"e_1_2_7_73_1","unstructured":"\u00a0"},{"key":"e_1_2_7_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201605674"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.12.025"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803094105"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2020.1721810"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.09.074"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107341"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT03470C"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00195A"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-010-0642-1"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9mt00051h"},{"key":"e_1_2_7_84_1","doi-asserted-by":"crossref","unstructured":"P. Konda L.\u2005M. Lifshits J.\u2005A. Roque 3rd H.\u2005D. Cole C.\u2005G. Cameron S.\u2005A. McFarland S. Gujar Oncoimmunology2020 10 1863626.","DOI":"10.1080\/2162402X.2020.1863626"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC04098F"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121371"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2018.02.006"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201900851"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC03975F"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202013987"},{"key":"e_1_2_7_91_1","first-page":"61","author":"Wang W. J.","year":"2021","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.738323"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1QI00856K"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5923609"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202115800"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15059"},{"key":"e_1_2_7_97_1","unstructured":"\u00a0"},{"key":"e_1_2_7_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00417-2"},{"key":"e_1_2_7_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0707-9"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000553"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020303"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202200270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/asia.202200270","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202200270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T18:06:03Z","timestamp":1759946763000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.202200270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,24]]},"references-count":101,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/asia.202200270"],"URL":"https:\/\/doi.org\/10.1002\/asia.202200270","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,24]]},"assertion":[{"value":"2022-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202200270"}}