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This protocol allows the synthesis of sterically hindered \u03b1\u2010arylated acetamides in moderate to high yields <jats:italic>via<\/jats:italic> 1,6\u2010addition of isocyanides to <jats:italic>p<\/jats:italic>\u2010quinone methides in the presence of BF<jats:sub>3<\/jats:sub>.OEt<jats:sub>2<\/jats:sub>. The present transformation features transition metal\u2010free conditions, avoiding the use of toxic carbon monoxide, broad substrate scope, mild reaction conditions, and operational simplicity.<\/jats:p>","DOI":"10.1002\/asia.202200642","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T03:24:10Z","timestamp":1660965850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Metal\u2010Free Aminocarbonylation of <i>p<\/i>\u2010Quinone Methides with Isocyanides: Synthesis of Sterically Hindered \u03b1\u2010Arylated Acetamides"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-8205","authenticated-orcid":false,"given":"Sachin R.","family":"Shirsath","sequence":"first","affiliation":[{"name":"Division of Organic Chemistry CSIR-National Chemical Laboratory  Pune 411 008 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devidas A.","family":"More","sequence":"additional","affiliation":[{"name":"Division of Organic Chemistry CSIR-National Chemical Laboratory  Pune 411 008 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2245-5498","authenticated-orcid":false,"given":"M.","family":"Muthukrishnan","sequence":"additional","affiliation":[{"name":"Division of Organic Chemistry CSIR-National Chemical Laboratory  Pune 411 008 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","unstructured":"B. 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