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All the bis\u2010amides were decorated with identical 3\u2010pyridyl amide of <jats:italic>L<\/jats:italic>\u2010phenylalanine moieties along with variously substituted terminal benzoyl groups. Gelation studies revealed that only 4\u2010methylphenyl substituted bis\u2010amide (<jats:bold>PME<\/jats:bold>) was capable of gelling both aqueous (DMSO\/water) and methyl salicylate (MS) (an important solvent for topical formulation for medical applications) solvents; whereas 4\u2010chlorophenyl and 4\u2010bromophenyl substituted bis\u2010amides (<jats:bold>PCL<\/jats:bold>, <jats:bold>PBR<\/jats:bold>, respectively) acted as organogelator for various organic solvents. On the contrary, 4\u2010nitrophenyl as well as 3,5\u2010dinitrophenyl substituted bis\u2010amides (<jats:bold>PNI<\/jats:bold>, <jats:bold>DNI<\/jats:bold>, respectively) were unable to gel any solvents studied herein. The corresponding aqueous gel namely <jats:bold>PME\u2010HG<\/jats:bold> and three methyl salicylate gels <jats:bold>PME\u2010MS<\/jats:bold>, <jats:bold>PCL\u2010MS<\/jats:bold> and <jats:bold>PBR\u2010MS<\/jats:bold> were characterized by dynamic and table top rheology followed by electron microscopy. Single crystal X\u2010ray diffraction (SXRD) data revealed crucial insights into the supramolecular assembly of all the gelator and nongelator bis\u2010amides. Both <jats:bold>PME\u2010HG<\/jats:bold> and <jats:bold>PME\u2010MS<\/jats:bold> were rheoreversible \u2013 an important property in material applications. Interestingly, <jats:bold>PME\u2010MS<\/jats:bold> displayed remarkable material properties such as shape\u2010sustaining, loadbearing and self\u2010healing. Selected MS and aqueous gels loaded with nano\u2010molar iodine were found to possess anti\u2010bacterial property as revealed by zone inhibition assay.<\/jats:p>","DOI":"10.1002\/asia.202200660","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T06:15:21Z","timestamp":1659334521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Supramolecular Gels from Bis\u2010amides of <i>L<\/i>\u2010Phenylalanine: Synthesis, Structure and Material Applications"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-5812","authenticated-orcid":false,"given":"Utsab","family":"Manna","sequence":"first","affiliation":[{"name":"School of Chemical Sciences, Indian Association for the Cultivation of Science  2A &amp; 2B Raja S. C. 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