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However, an efficient strategy to synthesize quinoline derivatives remains challenging. Herein, we describe an efficient and practical method for the synthesis of quinolines by Cu\u2010catalyzed cyclization of 2\u2010amino benzyl alcohol with ketones (or secondary alcohols) via an acceptorless dehydrogenation pathway. Interestingly, a range of highly functionalized quinolines is prepared in good yields using low catalyst loading under relatively mild conditions. Furthermore, density functional theory (DFT) calculations are carried out to investigate mechanistic insights for the acceptorless dehydrogenation pathway.<\/jats:p>","DOI":"10.1002\/asia.202200909","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T10:03:48Z","timestamp":1663322628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cu\u2010catalyzed Synthesis of Quinolines by Dehydrogenative Reaction of 2\u2010Aminobenzyl Alcohol and Ketones: A Combined Experimental and Computational Study"],"prefix":"10.1002","volume":"17","author":[{"given":"Minh","family":"Tuan Ha","sequence":"first","affiliation":[{"name":"Faculty of Chemistry VNU-Ha Noi University of Science  19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Thi Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry VNU-Ha Noi University of Science  19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc","family":"Huyen Tran","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry VNU-Ha Noi University of Science  19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quoc","family":"Viet Ho","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry VNU-Ha Noi University of Science  19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Thi Son","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry VNU-Ha Noi University of Science  19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Ha","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry VNU-Ha Noi University of Science  19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Hanoi National University of Education (HNUE)  136 Xuan Thuy, Cau Giay Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang","family":"Van Do","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry VNU-Ha Noi University of Science  19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran","family":"Quang Hung","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnamese Academy of Science and Technology (VAST)  18 Hoang Quoc Viet Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-1417","authenticated-orcid":false,"given":"Binh","family":"Khanh Mai","sequence":"additional","affiliation":[{"name":"Department of Chemistry Institution: University of Pittsburgh  15260 Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Thanh Dang","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry VNU-Ha Noi University of Science  19 Le Thanh Tong, Phan Chu Trinh, Hoan Kiem Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"\u00a0"},{"key":"e_1_2_9_2_2","volume-title":"Heterocyclic Chemistry","author":"Joule J. 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