{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:27:04Z","timestamp":1781270824777,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22073081"],"award-info":[{"award-number":["22073081"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The FeCl<jats:sub>3<\/jats:sub>\u2010catalyzed aerobic oxidation of ketones always gives rise to the \u03b1\u2010C\u2212C cleavage product, having challenges to afford hydroxyl keto compounds. Here we report an effective control of the main product from keto acid to \u03b1\u2010hydroxyl ketone, by reducing the concentration of FeCl<jats:sub>3<\/jats:sub> catalyst, together with the use of DMSO as the solvent. In addition, mechanistic investigations suggested the same FeCl<jats:sub>3<\/jats:sub>\u2010coordinated peroxide intermediate for both hydroxylation and C\u2212C cleavage routes, and emphasize the role of DMSO as both ligand and reductant. This work provides a new approach for selective aerobic oxidation under Lewis acid catalysis.<\/jats:p>","DOI":"10.1002\/asia.202201101","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T05:40:17Z","timestamp":1671082817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Control of Selectivity in FeCl<sub>3<\/sub>\u2010Catalyzed Aerobic Oxidation of Cycloketones"],"prefix":"10.1002","volume":"18","author":[{"given":"Qi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Chemistry and ZJU-NHU United R&amp;D Center Zhejiang University  Zhe Da Rd. 38 Hangzhou 310027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9153-8890","authenticated-orcid":false,"given":"Yongtao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and ZJU-NHU United R&amp;D Center Zhejiang University  Zhe Da Rd. 38 Hangzhou 310027 P. R. China"},{"name":"Center of Chemistry for Frontier Technologies Zhejiang University  Zhe Da Rd. 38 Hangzhou 310027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and ZJU-NHU United R&amp;D Center Zhejiang University  Zhe Da Rd. 38 Hangzhou 310027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and ZJU-NHU United R&amp;D Center Zhejiang University  Zhe Da Rd. 38 Hangzhou 310027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-5973","authenticated-orcid":false,"given":"Jia","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Chemistry and ZJU-NHU United R&amp;D Center Zhejiang University  Zhe Da Rd. 38 Hangzhou 310027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-9166","authenticated-orcid":false,"given":"Zeyu","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and ZJU-NHU United R&amp;D Center Zhejiang University  Zhe Da Rd. 38 Hangzhou 310027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-8731","authenticated-orcid":false,"given":"Haoran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry and ZJU-NHU United R&amp;D Center Zhejiang University  Zhe Da Rd. 38 Hangzhou 310027 P. R. China"},{"name":"State Key Laboratory of Chemical Engineering and College of Chemical and Biological Engineering Zhejiang University  Zhe Da Rd. 38 Hangzhou 310027 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201804946"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201804946"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00108"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr100197z"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/b807234e"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2009.06.024"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcata.2006.05.051"},{"key":"e_1_2_8_8_1","unstructured":"\u00a0"},{"key":"e_1_2_8_9_2","volume-title":"Ullmann's Encyclopedia of Industrial Chemistry","author":"Teles J. H.","year":"2015"},{"key":"e_1_2_8_10_2","volume-title":"Modern Oxidation Methods","author":"Backvall J.-E.","year":"2011"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcata.2004.08.028"},{"key":"e_1_2_8_12_1","unstructured":"\u00a0"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202001032"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c00708"},{"key":"e_1_2_8_15_1","unstructured":"\u00a0"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.09.024"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200705329"},{"key":"e_1_2_8_17_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200705329"},{"key":"e_1_2_8_18_2","doi-asserted-by":"crossref","unstructured":"C. Lucas-Lopez S. Patterson T. Blum A.\u2005F. Straight J. Toth A.\u2005M.\u2005Z. Slawin T.\u2005J. Mitchison J.\u2005R. Sellers N.\u2005J. Westwood Eur. J. Org. Chem.2005 1736\u20131740;","DOI":"10.1002\/ejoc.200500103"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.2.6"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00016a030"},{"key":"e_1_2_8_21_1","unstructured":"\u00a0"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2015.03.116"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2005.08.057"},{"key":"e_1_2_8_24_1","unstructured":"\u00a0"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b08347"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja108396k"},{"key":"e_1_2_8_27_1","unstructured":"\u00a0"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b00583"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201308698"},{"key":"e_1_2_8_29_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201308698"},{"key":"e_1_2_8_30_1","unstructured":"\u00a0"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1661-6124"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202014478"},{"key":"e_1_2_8_32_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202014478"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b01616"},{"key":"e_1_2_8_34_1","unstructured":"\u00a0"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.200900020"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202012720"},{"key":"e_1_2_8_36_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202012720"},{"key":"e_1_2_8_37_1","unstructured":"\u00a0"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2014.11.141"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9GC01357A"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00155a051"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcata.2021.118304"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1712067"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01396911"},{"key":"e_1_2_8_44_1","unstructured":"\u00a0"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.05.052"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1087674"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202201101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/asia.202201101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202201101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:17:24Z","timestamp":1759929444000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.202201101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/asia.202201101"],"URL":"https:\/\/doi.org\/10.1002\/asia.202201101","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"2022-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202201101"}}