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The reaction of 1,6\u2010enynes with formaldehyde in the presence of a cationic Rh(I) catalyst, such as [Rh(cod)<jats:sub>2<\/jats:sub>]<jats:sup>+<\/jats:sup>OTf<jats:sup>\u2212<\/jats:sup>, and a chiral biaryl diphosphine led to asymmetric cyclohydroformylation to produce aldehydes with higher\u2010order structures highly enantioselectively. This transformation procedure is applicable to a variety of enynes, with wide compatibility in various atoms liking between the alkyne and alkene parts, substituents at the alkyne terminus, and substituents at the alkene part, being converted to newly formed aldehydes in 14% to 90% yields with 50% to 98% <jats:italic>ee<\/jats:italic>. The products were further transformed with various nucleophiles to alcohols, an amine, and a diene without loss of chirality at their \u03b3\u2010position.<\/jats:p>","DOI":"10.1002\/asia.202201241","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:08:01Z","timestamp":1673914081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cationic Rhodium(I)\u2010Catalyzed Asymmetric Cyclohydroformylation of 1,6\u2010Enynes with Formaldehyde"],"prefix":"10.1002","volume":"18","author":[{"given":"Erin","family":"Hayashi","sequence":"first","affiliation":[{"name":"Division of Materials Science Graduate School of Science and Technology Nara Institute of Science and Technology (NAIST)  Ikoma Nara 630-0192 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Division of Materials Science Graduate School of Science and Technology Nara Institute of Science and Technology (NAIST)  Ikoma Nara 630-0192 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyomi","family":"Kakiuchi","sequence":"additional","affiliation":[{"name":"Division of Materials Science Graduate School of Science and Technology Nara Institute of Science and Technology (NAIST)  Ikoma Nara 630-0192 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-3573","authenticated-orcid":false,"given":"Tsuyoshi","family":"Kawai","sequence":"additional","affiliation":[{"name":"Division of Materials Science Graduate School of Science and Technology Nara Institute of Science and Technology (NAIST)  Ikoma Nara 630-0192 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1956-8777","authenticated-orcid":false,"given":"Tsumoru","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Division of Materials Science Graduate School of Science and Technology Nara Institute of Science and Technology (NAIST)  Ikoma Nara 630-0192 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"For selected books and recent reviews on hydroformylation reaction see:"},{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","unstructured":"M. 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