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In this study, we developed stimuli\u2010responsive hydrogels based on monomethoxy poly(ethylene glycol) (mPEG)\u2010polypeptide block copolymers containing various tertiary amine pendants (EEP\u2010TAs). The EEP\u2010TAs were synthesized via ring\u2010opening copolymerization of \u03b1\u2010amino acid <jats:italic>N<\/jats:italic>\u2010carboxyanhydrides, and further modified post\u2010polymerization with click chemistry. The EEP\u2010TAs exhibited an \u03b1\u2010helix\u2010to\u2010\u03b2\u2010sheet transition when the pH was increased from 4.0 to 7.4. At elevated polymer concentrations, aqueous solutions of the EEP\u2010TAs underwent thermo\u2010induced sol\u2013gel phase transitions, which were dependent on the pH. The hydrogels almost fully degraded within 3\u2005weeks in the subcutaneous layer of mice and exhibited good histocompatibility in\u2005vivo. Additionally, doxorubicin (DOX)\u2010loaded hydrogels exhibited pH\u2010responsive drug release profiles in\u2005vitro, which were composed of rapid release at acidic pH and more sustained release at neutral pH. Thus, these polypeptide hydrogels hold potential as depots for environment\u2010responsive delivery of therapeutic agents.<\/jats:p>","DOI":"10.1002\/asia.202300021","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T09:30:18Z","timestamp":1677663018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["pH\u2010 and Temperature\u2010responsive Hydrogels Based on Tertiary Amine\u2010modified Polypeptides for Stimuli\u2010responsive Drug Delivery"],"prefix":"10.1002","volume":"18","author":[{"given":"Zhiqiang","family":"Lin","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences  130022 Changchun Jilin P.\u2005R. China"},{"name":"University of Science and Technology of China  230026 Hefei Anhui P.\u2005R. 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