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In this work, we synthesized two new halogen\u2010functionalized aggregation\u2010induced emission (AIE)\u2010active molecules, DQMF\u2010OH and DQMCl\u2010OH, based on the quinoline\u2010malononitrile chromophore. The halogen effect on the photophysical characteristics was detailedly studied by absorption and fluorescence spectroscopy, density functional theory calculations, and crystal structures. Compared with non\u2010halogen substituted AIE luminogen (AIEgen) DQM\u2010OH, the halogen substituted DQMF\u2010OH and DQMCl\u2010OH exhibited red\u2010shifted absorptions and emissions in the solution and solid state. In addition, DQMF\u2010OH and DQMCl\u2010OH also possessed enhanced fluorescence toward viscosity changes. These AIEgens served as remarkable imaging tools for cell tracking in a wash\u2010free manner. Furthermore, DQMF\u2010OH and DQMCl\u2010OH showed much more excellent photobleaching resistance than DQM\u2010OH. Our work sheds new light on developing fluorescent halogenated dyes with enhanced photophysical performances for biological applications.<\/jats:p>","DOI":"10.1002\/asia.202300163","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T04:13:50Z","timestamp":1680927230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Halogenation on Quinoline\u2010Malononitrile\u2010based AIEgens: Photophysical Properties Investigation and Wash\u2010Free Imaging"],"prefix":"10.1002","volume":"18","author":[{"given":"Lu","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Crystal Materials Shandong University  Jinan 250100 P. R. 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