{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:07:35Z","timestamp":1780081655610,"version":"3.54.0"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22077060"],"award-info":[{"award-number":["22077060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22205097"],"award-info":[{"award-number":["22205097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photodynamic therapy (PDT) is recognized to be a promising strategy for anticancer treatment. Considering the progressive application of PDT in clinical trials, highly efficient photosensitizers (PSs) are in strong demand. Aggregation\u2010induced emission (AIE) based PSs are promising phototheranostic materials for tumor imaging and PDT due to their high fluorescence and photosensitizing efficiency. Herein, a PS, TPA\u20102BCP with AIE characteristics is developed by adopting an acceptor\u2010\u03c0\u2010donor\u2010\u03c0\u2010acceptor (A\u2013\u03c0\u2013D\u2013\u03c0\u2013A) structure. However, the accumulation of ionic PSs in the tumor is poor due to non\u2010specific interactions with bio\u2010molecules. Therefore, we use a carboxyl\u2010rich polymer material, polyacrylate polyethylene glycol block copolymer (PEG\u2010<jats:italic>b<\/jats:italic>\u2010PAA) to encapsulate the cationic PSs into nanoparticles through ionic interactions. The cationic groups are blocked and the generated PS nanoparticles can accumulate well in the tumor site <jats:italic>in\u2005vivo<\/jats:italic>. Meanwhile, the photosensitizing efficiency of the PS is further enhanced in the nanoparticle format. The tumor growth can be obviously inhibited under 530\u2005nm laser irradiation, demonstrating its potential application in antitumor PDT.<\/jats:p>","DOI":"10.1002\/asia.202300212","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T04:13:53Z","timestamp":1680927233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Combination of PEG\u2010<i>b<\/i>\u2010PAA Carrier and Efficient Cationic Photosensitizers for Photodynamic Therapy"],"prefix":"10.1002","volume":"18","author":[{"given":"Hui","family":"Yang","sequence":"first","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhao","family":"Shang","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiankun","family":"Shi","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jucai","family":"Gao","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-0716","authenticated-orcid":false,"given":"Fang","family":"Hu","sequence":"additional","affiliation":[{"name":"Biomaterials Research Center School of Biomedical Engineering Southern Medical University  Guangzhou 510515 China"},{"name":"Microbiome Medicine Center Department of Laboratory Medicine Zhujiang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.191008.001"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0410-2"},{"key":"e_1_2_8_3_1","unstructured":"D. Luo K. Carter D. Miranda J. Lovell Baden-Wurttemberg Ger Weinheim Adv. Sci.2017."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.049"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900132"},{"key":"e_1_2_8_6_1","unstructured":"\u00a0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00173B"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC05454J"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.2c03274"},{"key":"e_1_2_8_10_2","author":"Sun Q.","year":"2022","journal-title":"Aggregate"},{"key":"e_1_2_8_11_1","unstructured":"\u00a0"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2584-8"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.103001"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000521"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB02393D"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100780"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900132"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202005785"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202005785"},{"key":"e_1_2_8_19_1","unstructured":"\u00a0"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01553-z"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202100291"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26020268"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801350"},{"key":"e_1_2_8_25_1","unstructured":"\u00a0"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b12375"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120934"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121255"},{"key":"e_1_2_8_29_1","unstructured":"\u00a0"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020459"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202002057"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2QM01043G"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202000046"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606167"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.7193"},{"key":"e_1_2_8_36_1","unstructured":"\u00a0"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b08398"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201802050"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.1"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC02001J"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c06872"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202200571"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202300212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:59:47Z","timestamp":1759924787000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.202300212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,25]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,5,16]]}},"alternative-id":["10.1002\/asia.202300212"],"URL":"https:\/\/doi.org\/10.1002\/asia.202300212","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,25]]},"assertion":[{"value":"2023-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300212"}}