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We describe herein a unique reactivity of 4\u2010Bpin\u2010\n                    <jats:italic>o<\/jats:italic>\n                    \u2010carborane with ketones under basic conditions, leading to sequential cage carbon alkylation, B\u2212B bond activation and unexpected O\u2010migration. The reaction was compatible with a good substrate scope including dialkyl or alkyl aryl ketones. The reaction mechanism is also proposed, involving cage CH deprotonation, nucleophilic attack of ketone, and O\u2010migration along with B\u2212B bond cleavage.\n                  <\/jats:p>","DOI":"10.1002\/asia.202300598","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T04:41:47Z","timestamp":1691383307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reaction of 4\u2010Bpin\u2010\n                    <i>o<\/i>\n                    \u2010Carborane with Ketones: Sequential Carbon Vertex Alkylation and B\u2212B Bond Activation"],"prefix":"10.1002","volume":"18","author":[{"given":"Zhen","family":"Nie","sequence":"first","affiliation":[{"name":"Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences, Chinese Academy of Sciences  345 Lingling Rd Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences, Chinese Academy of Sciences  345 Lingling Rd Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-7027","authenticated-orcid":false,"given":"Zaozao","family":"Qiu","sequence":"additional","affiliation":[{"name":"Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences, Chinese Academy of Sciences  345 Lingling Rd Shanghai 200032 China"},{"name":"School of Chemistry and Materials Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  1 Sub-lane Xiangshan Hangzhou 310024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-004X","authenticated-orcid":false,"given":"Zuowei","family":"Xie","sequence":"additional","affiliation":[{"name":"Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences, Chinese Academy of Sciences  345 Lingling Rd Shanghai 200032 China"},{"name":"Department of Chemistry The Chinese University of Hong Kong  Shatin, N. 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