{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:05Z","timestamp":1786977125848,"version":"build-2736575974"},"reference-count":135,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374065"],"award-info":[{"award-number":["22374065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2024,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Malignant tumors seriously threaten human life and well\u2010being. Emerging Near\u2010infrared II (NIR\u2010II, 1000\u20131700\u2005nm) phototheranostic nanotechnology integrates diagnostic and treatment modalities, offering merits including improved tissue penetration and enhanced spatiotemporal resolution. This remarkable progress has opened promising avenues for advancing tumor theranostic research. The tumor microenvironment (TME) differs from normal tissues, exhibiting distinct attributes such as hypoxia, acidosis, overexpressed hydrogen peroxide, excess glutathione, and other factors. Capitalizing on these attributes, researchers have developed TME\u2010activatable NIR\u2010II phototheranostic agents with diagnostic and therapeutic attributes concurrently. Therefore, developing TME\u2010activatable NIR\u2010II phototheranostic agents with diagnostic and therapeutic activation holds significant research importance. Currently, research on TME\u2010activatable NIR\u2010II phototheranostic agents is still in its preliminary stages. This review examines the recent advances in developing dual\u2010functional NIR\u2010II activatable phototheranostic agents over the past years. It systematically presents NIR\u2010II phototheranostic agents activated by various TME factors such as acidity (pH), hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), glutathione (GSH), hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), enzymes, and their hybrid. This encompasses NIR\u2010II fluorescence and photoacoustic imaging diagnostics, along with therapeutic modalities, including photothermal, photodynamic, chemodynamic, and gas therapies triggered by these TME factors. Lastly, the difficulties and opportunities confronting NIR\u2010II activatable phototheranostic agents in the simultaneous diagnosis and treatment field are highlighted.\n                  <\/jats:p>","DOI":"10.1002\/asia.202301036","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T04:43:46Z","timestamp":1705466626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Recent Progress on Tumor Microenvironment\u2010Activated NIR\u2010II Phototheranostic Agents with Simultaneous Activation for Diagnosis and Treatment"],"prefix":"10.1002","volume":"19","author":[{"given":"Hao","family":"Xiao","sequence":"first","affiliation":[{"name":"Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School University of South China  28, West Changsheng Road Hengyang City, Hunan Province 421001 China"},{"name":"MOE Key Lab of Rare Pediatric Diseases, Hengyang 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