{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:34:36Z","timestamp":1780529676346,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211265"],"award-info":[{"award-number":["BK20211265"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22178306"],"award-info":[{"award-number":["22178306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LGC22B050013"],"award-info":[{"award-number":["LGC22B050013"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We presented a NIR\u2010driven Janus Cu<jats:sub>2<\/jats:sub>O\/Au nanomotor. The nanomotor has a truncated octahedral structure. By asymmetric Au evaporation, the light response range of Cu<jats:sub>2<\/jats:sub>O nanomotor is extended to near\u2010infrared range, and the speed of Cu<jats:sub>2<\/jats:sub>O\/Au nanomotors under NIR is significantly increased. In promoting apoptosis of hepatocellular carcinoma, except the nanotoxicity of Cu<jats:sub>2<\/jats:sub>O itself, the Au layer enhances the photothermal properties, allowing Cu<jats:sub>2<\/jats:sub>O\/Au nanomotors to induce apoptosis in hepatocellular carcinoma cells by heating them. On the other hand, a Schottky barrier formed at the interface of Cu<jats:sub>2<\/jats:sub>O and Au, preventing the recombination of electrons, which makes more electrons react with biomolecules to produce toxic ROS to kill hepatocellular cells. The killing rate of hepatocellular carcinoma cells reached 87\u2009% by the combined effect of nanotoxicity inhibition of proliferation and photothermal &amp; photodynamic therapy (PTT &amp; PDT). Nanomotors in combination with multiple approaches are explored as a new treatment to tumor in this article.<\/jats:p>","DOI":"10.1002\/asia.202301137","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T10:44:19Z","timestamp":1706525059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["NIR\u2010Mediated Cu<sub>2<\/sub>O\/Au Nanomotors for Synergistically Treating Hepatoma Carcinoma Cells"],"prefix":"10.1002","volume":"19","author":[{"given":"Ting","family":"Xian","sequence":"first","affiliation":[{"name":"Research Institute for Biomaterials Tech Institute for Adv. Mater. College of Materials Science and Engineering Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Institute for Biomaterials Tech Institute for Adv. Mater. College of Materials Science and Engineering Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingtao","family":"Song","sequence":"additional","affiliation":[{"name":"Research Institute for Biomaterials Tech Institute for Adv. Mater. College of Materials Science and Engineering Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological Engineering Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0572-5310","authenticated-orcid":false,"given":"Wenjuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Institute for Biomaterials Tech Institute for Adv. Mater. College of Materials Science and Engineering Nanjing Tech University  Nanjing 211816 China"},{"name":"Jiangsu Collaborative Innovation Center for Advanced Inorganic Functional Composites Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Gu","sequence":"additional","affiliation":[{"name":"Research Institute for Biomaterials Tech Institute for Adv. Mater. College of Materials Science and Engineering Nanjing Tech University  Nanjing 211816 China"},{"name":"Jiangsu Collaborative Innovation Center for Advanced Inorganic Functional Composites Nanjing Tech University  Nanjing 211816 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30143-7"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33313"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.061"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.09.034"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108852"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.11.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202103978"},{"key":"e_1_2_8_11_1","volume":"29","author":"Xu T.","year":"2016","journal-title":"Adv. Mater."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201970112"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM00845A"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b05940"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202101178"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2021.101200"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b17563"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.103469"},{"key":"e_1_2_8_19_1","unstructured":"\u00a0"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15591-4"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004647"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b09387"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NH00663G"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2010.02.002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2015.12.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR08088J"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.11.018"},{"key":"e_1_2_8_28_1","first-page":"357","volume":"7","author":"Wang L.","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.81845"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lpor.201200003"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001806"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn102722z"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-020-03464-0"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3592"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR04512A"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001236"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202301137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:23:13Z","timestamp":1759940593000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.202301137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,4,2]]}},"alternative-id":["10.1002\/asia.202301137"],"URL":"https:\/\/doi.org\/10.1002\/asia.202301137","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"2023-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202301137"}}