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In vitro profiling using the stopped\u2010flow technique revealed that veralipride exhibited potent inhibitory activity across all tested hCA isoforms, with exception of hCA III. Comparative analysis with standard inhibitors, acetazolamide (AAZ), and sulpiride, provided insights for understanding the relative efficacy of veralipride as CA inhibitor. The study reports the X\u2010ray crystal structure analysis of the veralipride adduct with three human (h) isoforms, hCA I, II, and CA XII mimic, allowing the understanding of the molecular interactions rationalizing its inhibitory effects against each isoform. These findings contribute to our understanding of veralipride pharmacological properties and for the design of structural analogs endowed with polypharmacological properties.<\/jats:p>","DOI":"10.1002\/asia.202400067","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T08:34:03Z","timestamp":1707467643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The dopamine D<sub>2<\/sub> receptors antagonist Veralipride inhibits carbonic anhydrases: solution and crystallographic insights on human isoforms"],"prefix":"10.1002","volume":"19","author":[{"given":"Andrea","family":"Angeli","sequence":"first","affiliation":[{"name":"NEUROFARBA Department Sezione di Scienze Farmaceutiche University of Florence  Via Ugo Schiff 6 50019 Sesto Fiorentino Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ferraroni","sequence":"additional","affiliation":[{"name":"Department of Chemistry \u201cUgo Schiff\u201d University of Florence  Via della Lastruccia 3\u201313 I-50019 Sesto Fiorentino Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[{"name":"Istituto di Bioscienze e Biorisorse, CNR  80131 Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department Sezione di Scienze Farmaceutiche University of Florence  Via Ugo Schiff 6 50019 Sesto Fiorentino Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)36394-3"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b02144"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697130903219208"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11774-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S12640"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(88)90025-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.5.5.695"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm5006463"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.11.014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115783"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.09.028"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2023.129411"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.602668"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1567488"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1122001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7359-2_15"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2023.2263914"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20110721"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802607780636762"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1548608"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180622120625"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2021-0207"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62326-9"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00938"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01911"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00362"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.04.004"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111600"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00443"},{"key":"e_1_2_9_32_1","first-page":"41","volume-title":"Procesing diffraction data with mosflm.","author":"Leslie A. 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