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A short PEG, tetraethylene glycol (<jats:bold>TEG<\/jats:bold>) was covalently attached with a neutral organic rotamer benzothiazole dye (<jats:bold>BTA\u20102<\/jats:bold>) affording the neutral <jats:bold>TEG\u2010BTA\u20102<\/jats:bold> (&lt;500 D). The <jats:bold>TEG\u2010BTA\u20102<\/jats:bold> is self\u2010assembled into a microsphere in an aqueous medium, but remarkably undergoes morphology change switching to a rice\u2010like microcapsule for curcumin encapsulation. Curcumin\u2010loaded microcapsules were stable in an aqueous solution, however, were noticed disintegrating upon the addition of BSA protein. This is possibly due to an interaction with BSA protein leading to a protein affinity\u2010controlled curcumin release in a neutral PBS buffer. Moreover, cell internalization of the neutral amphiphile <jats:bold>TEG\u2010BTA\u20102<\/jats:bold> into A549 cells was observed by fluorescence microscopy, providing an opportunity for application as a molecular vehicle for targeted drug delivery and monitoring.<\/jats:p>","DOI":"10.1002\/asia.202400144","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T05:41:05Z","timestamp":1710481265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual Functional Microcapsule based on Monodisperse Short PEG Amphiphile for Drug Encapsulation and Protein Affinity Controlled Release"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9202-7283","authenticated-orcid":false,"given":"Rohit N.","family":"Ketkar","sequence":"first","affiliation":[{"name":"Department of Speciality Chemicals Technology Institute of Chemical Technology  Matunga (E) Mumbai Maharashtra 400019 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paritosh","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Speciality Chemicals Technology Institute of Chemical Technology  Matunga (E) Mumbai Maharashtra 400019 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Triveni","family":"Sodnawar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Savitribai Phule Pune University  Ganeshkind Road Pune Maharashtra 411007 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpy","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Savitribai Phule Pune University  Ganeshkind Road Pune Maharashtra 411007 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manikandan","family":"M","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry and Cell Biology Laboratory Department of Chemical Sciences Tata Institute of Fundamental Research  Homi Bhabha Road Mumbai Maharashtra 400005 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharmistha","family":"Dutta Choudhury","sequence":"additional","affiliation":[{"name":"Bhabha Atomic Research Centre  Mumbai 400085 India."},{"name":"Homi Bhabha National Institute Anushaktinagar  Mumbai 400094 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-9469","authenticated-orcid":false,"given":"Nabanita","family":"Sadhukhan","sequence":"additional","affiliation":[{"name":"Department of Speciality Chemicals Technology Institute of Chemical Technology  Matunga (E) Mumbai Maharashtra 400019 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4750"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200806000"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214081"},{"key":"e_1_2_9_4_1","unstructured":"\u00a0"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/mp100356k"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200907223"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-021-00439-4"},{"key":"e_1_2_9_8_1","unstructured":"\u00a0"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902672"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200900218"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/b920570p"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.10.015"},{"key":"e_1_2_9_13_2","first-page":"4167","volume":"97","author":"Psimadas D.","year":"2007","journal-title":"J. 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