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However, traditional red\/NIR fluorophores often exhibit weak emission at high concentrations or in an aggregated state due to the aggregate\u2010caused quenching effect, which severely limits their applicability in biological imaging. To address this challenge, we developed a series of cyanostyrene derivatives with aggregation\u2010induced emission characteristics, including 2,3\u2010Bis\u2010(4\u2010styryl\u2010phenyl)\u2010but\u20102\u2010enedinitrile (DPB), 2,3\u2010Bis\u2010{4\u2010[2\u2010(4\u2010methoxy\u2010 phenyl)\u2010vinyl]\u2010phenyl}\u2010but\u20102\u2010enedinitrile (DOB), 2,3\u2010Bis\u2010{4\u2010[2\u2010(4\u2010diphenylamino\u2010 phenyl)\u2010vinyl]\u2010phenyl}\u2010but\u20102\u2010enedinitrile (DTB), and 2,3\u2010Bis\u2010[4\u2010(2\u2010{4\u2010[phenyl\u2010 (4\u2010triphenylvinyl\u2010phenyl)\u2010amino]\u2010phenyl}\u2010vinyl)\u2010 phenyl]\u2010but\u20102\u2010enedinitrile (DTTB). Notably, these compounds exhibited intense solid state fluorescence owing to AIE effect, especially DTTB shows NIR emission with high solid state quantum efficiency (712\u2005nm, \u03a6<jats:sub>F<\/jats:sub>=14.2\u2009%). Then we prepared DTTB@PS\u2010PEG NPs nanoparticles by encapsulating DTTB with the amphiphilic polymer polystyrene\u2010polyethylene glycol (PS\u2010PEG). Importantly, DTTB@PS\u2010PEG NPs exhibited highly efficient NIR luminescence (\u03a6<jats:sub>F<\/jats:sub>=28.7\u2009%) and a large two\u2010photon absorption cross\u2010section (1900\u2005GM) under 800\u2005nm laser excitation. The bright two\u2010photon fluorescence of DTTB@PS\u2010PEG indicated that it can be a highly promising candidate for two\u2010photon fluorescence probe. Therefore, this work provides valuable insights for the design of highly efficient and NIR\u2010emitting two\u2010photon fluorescent probes.<\/jats:p>","DOI":"10.1002\/asia.202400533","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T21:59:49Z","timestamp":1718143189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficient Near\u2010Infrared Fluorophores Based on Cyanostyrene Derivatives for Two\u2010Photon Fluorescence Bioimaging"],"prefix":"10.1002","volume":"19","author":[{"given":"Xue","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Gynecology and Obstetrics Centre The First Hospital of Jilin University  Changchun 130021 China"},{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology  PLA general hospital Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric oncology The First Hospital of Jilin University  Changchun 130021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jilin Provincial Experimental School  Changchun 130021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology center The First Hospital of Jilin University  Changchun 130021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5766-8050","authenticated-orcid":false,"given":"Wenjing","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology  PLA general hospital Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CS15205J"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11687"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2021.100631"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtadv.2020.100058"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c17476"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7TB02399E"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c08605"},{"key":"e_1_2_9_8_1","volume":"12","author":"Li Z.","year":"2021","journal-title":"Nat. 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