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The C\u2212H activation has been one of the most powerful tools in organic synthesis. These reactions are often assisted by solvents which not only provide a medium for the chemical reactions but also facilitate reaching to the product stage. The solvent helps the reaction profile both chemically and energetically to reach the targeted product. Organic transformations <jats:italic>via<\/jats:italic> C\u2212H activation from the solvent assistance perspective has been discussed in this review. Various solvents such as tetrahydrofuran (THF), MeCN, dichloromethane (DCM), dimethoxyethane (DME), 1,2\u2010dichloroethane (1,2\u2010DCE), dimethylformamide (DMF), dimethylsulfoxide (DMSO), isopropyl nitrile (<jats:sup>i<\/jats:sup>PrCN), 1,4\u2010dioxane, AcOH, trifluoroacetic acid (TFA), Ac<jats:sub>2<\/jats:sub>O, PhCF<jats:sub>3<\/jats:sub>, chloroform (CHCl<jats:sub>3<\/jats:sub>), H<jats:sub>2<\/jats:sub>O, N\u2010methylpyrrolidone (NMP), acetone, methyl <jats:italic>tert<\/jats:italic>\u2010butyl ether (MTBE), toluene, <jats:italic>p<\/jats:italic>\u2010xylene, alcohols, MeOH, 1,1,1\u2010trifluoroethanol (TFE), 1,1,1,3,3,3\u2010hexafluoroisopropanol (HFIP), <jats:italic>tert\u2010<\/jats:italic>amyl alcohol and their roles are discussed. The exclusive role of the solvent in various transformations has been deliberated by highlighting the substrate scope, along with the proposed mechanisms. For easy classification, the review has been divided into three parts: (i) solvent\u2010switched divergent C\u2212H activation; (ii) C\u2212H bond activation with solvent as the coupling reagent, and (iii) C\u2212H activation with solvent caging and solvent\u2010assisted electron donor acceptor (EDA) complex formation and autocatalysis.<\/jats:p>","DOI":"10.1002\/asia.202400603","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:23:31Z","timestamp":1730993011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Solvent Dictated Organic Transformations"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-2551","authenticated-orcid":false,"given":"Tamanna","family":"Khandelia","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Guwahati  Assam 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