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Initially, we synthesized 2\u2010aminobenzonitriles containing an organic selenium moiety, resulting in sixteen compounds with various substituents linked to the portion derived from diorganyl diselenide. These compounds were then used as substrates in reactions with cyclic ketones, in the presence of 1.4 equivalents of trifluoroboroetherate as a Lewis acid, to synthesize selenylated analogs of Tacrine with yields ranging from 20\u2009% to 87\u2009%. <jats:italic>In silico<\/jats:italic> studies explored computational parameters related to antioxidant activity and hepatotoxicity. <jats:italic>In vitro<\/jats:italic> studies elucidated the antioxidant effects of Tacrine and its selenium hybrid (TSe) in neutralizing ABTS radicals, scavenging DPPH radicals, and reducing iron ions. Additionally, the acute oral toxicity of one synthesized compound was evaluated.<\/jats:p>","DOI":"10.1002\/asia.202400637","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T10:56:10Z","timestamp":1720608970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Selenylated Analogs of Tacrine: Synthesis, <i>In Silico<\/i> and <i>In Vitro<\/i> Studies of Toxicology and Antioxidant Properties"],"prefix":"10.1002","volume":"19","author":[{"given":"Manoela","family":"do Sacramento","sequence":"first","affiliation":[{"name":"LASOL-CCQFA Universidade Federal de Pelotas \u2013 UFPel  P.O. Box 354 96010\u2013900 Pelotas, RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto B.","family":"Morais","sequence":"additional","affiliation":[{"name":"LASOL-CCQFA Universidade Federal de Pelotas \u2013 UFPel  P.O. 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