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Recently, despite significant progress in combating this parasitic disease, malaria remains a major global health concern, especially in areas with limited resources and vulnerable populations. Consequently, identifying and developing effective agents to combat malaria and its associated dysfunctions is essential therefore the two new Schiff base ligands incorporated Co(II), Ni(II), Cu(II) and Zn(II) ions were synthesized and thoroughly characterized. The synthesized compounds were assessed for <jats:italic>in\u2005vitro<\/jats:italic> anti\u2010malarial and antimicrobial efficacy, compounds (<jats:bold>9, 10<\/jats:bold>) demonstrated highest potential with IC<jats:sub>50<\/jats:sub>=1.08\u00b10.09 to 1.18\u00b10.04\u2005\u03bcM against <jats:italic>P. falciparum<\/jats:italic> and MIC=0.0058\u2005\u03bcmol\/mL against <jats:italic>C. albicans<\/jats:italic> and <jats:italic>E. coli<\/jats:italic>, respectively. The complexes (<jats:bold>5, 6<\/jats:bold>) were effectively reduce mitigate oxidative stress with lowest IC<jats:sub>50<\/jats:sub> value of 2.69\u00b10.12 to 2.87\u00b10.09\u2005\u03bcM. Moreover, the biological findings were reinforced by a molecular docking investigation involving the potential compounds (<jats:bold>2, 7\u201310<\/jats:bold>) against dihydroorotate dehydrogenase and sterol 14\u2010alpha demethylase proteins which exposed complex's excellent biological response than their parent ligands. ADMET profiling was used to confirm the compounds\u2019 oral drug\u2010like features. This research offers promising prospects for future multi\u2010functional drug innovations targeting malaria, pathogenic infections, and oxidative stress.<\/jats:p>","DOI":"10.1002\/asia.202400676","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T02:53:52Z","timestamp":1721703232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Unveiling Anti\u2010Malarial, Antimicrobial, Antioxidant Efficiency and Molecular Docking Study of Synthesized Transition Metal Complexes Derived From Heterocyclic Schiff Base Ligands"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2253-4786","authenticated-orcid":false,"given":"Manju","family":"Rani","sequence":"first","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science and Technology  Hisar 125001, Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-3193","authenticated-orcid":false,"given":"Jai","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science and Technology  Hisar 125001, Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-9974","authenticated-orcid":false,"given":"Binesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science and Technology  Hisar 125001, Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9408-578X","authenticated-orcid":false,"given":"Manisha","family":"Rathi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Jambheshwar University of Science and Technology  Hisar 125001, Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-016-0151-8"},{"key":"e_1_2_9_2_1","unstructured":"WHO World Malaria Report 2023 World Health Organization Geneva2023. 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