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We report here a microwave\u2010enhanced synthesis of these compounds starting from non\u2010activated <jats:italic>N\u2010<\/jats:italic>alkyl aziridines in the presence of catalytic amounts of simple ammonium metallates. A remarkable TOF of 2787.9\u2005h<jats:sup>\u22121<\/jats:sup> has been observed in the case of [TBA]<jats:sub>2<\/jats:sub>[ZnI<jats:sub>4<\/jats:sub>] as the catalyst (catalyst loading 0.1\u2005mol\u2009%) and with an almost complete selectivity (up to 97\u2009%) in favor of both diastereoisomers (<jats:italic>meso<\/jats:italic> and chiral form) of the target 2,5\u2010disubstituted piperazines, obtained in 1\u2009:\u20091 ratio. The two isomers are easily separated, because the <jats:italic>meso<\/jats:italic> form precipitates in pure from the reaction crude. A stereochemical investigation and the unprecedented isolation of 2,6\u2010disubstituted <jats:italic>N<\/jats:italic>,<jats:italic>N\u2019<\/jats:italic>\u2010alkylpiperazines allowed us to shed light on the reaction mechanism.<\/jats:p>","DOI":"10.1002\/asia.202400688","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T08:30:32Z","timestamp":1723537832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ammonium Zincates as Catalysts for the Microwave\u2010Enhanced Synthesis of Symmetric Piperazines by Regioselective Opening of Aziridines"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-9314","authenticated-orcid":false,"given":"Matteo","family":"Alberti","sequence":"first","affiliation":[{"name":"Department of Chemistry Universit\u00e0 degli Studi di Milano and CNR-SCITEC  Via Golgi 19 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5811-849X","authenticated-orcid":false,"given":"Andrea","family":"Dariol","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universit\u00e0 degli Studi di Milano and CNR-SCITEC  Via Golgi 19 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-9741","authenticated-orcid":false,"given":"Nicola","family":"Panza","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universit\u00e0 degli Studi di Milano and CNR-SCITEC  Via Golgi 19 20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-4127","authenticated-orcid":false,"given":"Giorgio","family":"Abbiati","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche - Sezione di Chimica Generale e Organica \u201cA. 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