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A fluorescent probe has been regarded as one of the most attractive approaches, which is compatible with living cells and possesses high sensitivity. However, most of fluorescent probes\u2019 reaction sites are activated before they reach the destination. In this work, an acid\u2010activatable fluorescent probe PT1 was synthesized, characterized, and used for SO<jats:sub>2<\/jats:sub> detection. The introduction of oxazolines in PT1 enables the intelligent response of probe to release the activation stie for SO<jats:sub>2<\/jats:sub> derivatives through Michael addition upon exposure to acid. In vitro studies showed a remarkable selectivity of PT1 to SO\u2082 derivatives than other biothiols with a limit of detection as low as 62\u2005nM. By using this acidic pH\u2010controlled fluorescence responsiveness to SO\u2082, precise spatiotemporal identification of lysosomal SO<jats:sub>2<\/jats:sub> fluctuations has been successfully performed. Furthermore, probe PT1 can be applied for monitoring SO\u2082 derivatives in traditional Chinese medicines.<\/jats:p>","DOI":"10.1002\/asia.202400716","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T06:53:32Z","timestamp":1721717612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An Acid\u2010Activatable Fluorescent Probe for Sulfur Dioxide in Traditional Chinese Medicines and Living Cells"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-1392","authenticated-orcid":false,"given":"Guan","family":"Xi","sequence":"first","affiliation":[{"name":"Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center  Jieyang 515200 China"},{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"},{"name":"Smart Medical Innovation Technology Center School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center  Jieyang 515200 China"},{"name":"School of Chemical Engineering and Light Industry Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peitao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nanfang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congting","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center  Jieyang 515200 China"},{"name":"School of Chemical Engineering and Light Industry Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center  Jieyang 515200 China"},{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"},{"name":"Smart Medical Innovation Technology Center School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center  Jieyang 515200 China"},{"name":"School of Chemical Engineering and Light Industry Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center  Jieyang 515200 China"},{"name":"School of Chemical Engineering and Light Industry Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiangang","family":"Luan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center  Jieyang 515200 China"},{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"},{"name":"Smart Medical Innovation Technology Center School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  100 Waihuanxi Road Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00992"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC03594J"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.09.007"},{"key":"e_1_2_7_5_1","unstructured":"\u00a0"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0213"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202305290"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","unstructured":"M. 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