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Chemosensor <jats:bold>NI<\/jats:bold>\u2010<jats:bold>SP<\/jats:bold> exhibited selective ratiometric fluorescent response to the presence of Hg<jats:sup>2+<\/jats:sup> in aqueous solution due to the interplay between resonance energy transfer (RET) and intramolecular charge transfer (ICT) processes occurred upon excitation. The observed switching of the ratio of emission intensities in the blue and red channels <jats:italic>R<\/jats:italic> was higher than in the case of monochromophoric styrylpyridine derivative <jats:bold>SP<\/jats:bold> showing ratiometric response based on ICT mechanism only. Biological studies revealed that <jats:bold>NI<\/jats:bold>\u2010<jats:bold>SP<\/jats:bold> penetrates into human lung adenocarcinoma A549 cells and accumulates in cytoplasm and lysosomes. When cells were pre\u2010incubated with mercury (II) perchlorate, the ratio <jats:italic>R<\/jats:italic> was increased 2.6 times, which enables detection of intracellular Hg<jats:sup>2+<\/jats:sup> ions and their quantitative analysis in the 0.7\u20136.0\u2005\u03bcM concentration range.<\/jats:p>","DOI":"10.1002\/asia.202400777","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T11:17:09Z","timestamp":1727090229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of RET Approach for Ratiometric Response Enhancement of ICT Fluorescent Hg<sup>2+<\/sup> Probe based on Crown\u2010containing Styrylpyridinium Dye"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8303-0245","authenticated-orcid":false,"given":"Pavel A.","family":"Panchenko","sequence":"first","affiliation":[{"name":"Laboratoty of Photoactive Supramolecular Systems, A. 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