{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T18:23:56Z","timestamp":1771525436819,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52203009"],"award-info":[{"award-number":["52203009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52333014"],"award-info":[{"award-number":["52333014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Developing activatable photodynamic agents is becoming a promising mode for realizing selective photodynamic therapy (PDT) in cancer treatment. However, till now only a few H<jats:sub>2<\/jats:sub>S\u2010activatable photodynamic agents have been involved in this field. Here, we fabricated H<jats:sub>2<\/jats:sub>S\u2010activatable nano\u2010assemblies (P@TPPCY) for the treatment of colon cancer containing high concentration H<jats:sub>2<\/jats:sub>S. The H<jats:sub>2<\/jats:sub>S\u2010activatable photosensitizer (TPPCY) was synthesized by covalent conjugation between tetraphenylporphyrin (TPP) and heptamethine cyanine (Cy7), and then TPPCY was encapsulated by an amphiphilic polymer DSPE\u2010mPEG to form P@TPPCY nano\u2010assemblies. We demonstrated that the photosensitizing effect of TPP was efficiently quenched by Cy7 with strong absorption in the NIR region <jats:italic>via<\/jats:italic> fluorescence resonance energy transfer (FRET) effect. Interestingly, the FRET effect between Cy7 and TPP was attenuated by the decrease of absorption of Cy7 in the NIR region after the Cy7 reacted with H<jats:sub>2<\/jats:sub>S, and then the photosensitizing effect of TPP in P@TPPCY was activated. Strikingly, the P@TPPCY showed efficient H<jats:sub>2<\/jats:sub>S\u2010activatable photodynamic therapy (PDT) in\u2005vitro against HCT116 cells (human colon carcinoma cell line), thus this work provides a new method for realizing accurate treatment of colon cancer in virtue of high H<jats:sub>2<\/jats:sub>S concentration microenvironment.<\/jats:p>","DOI":"10.1002\/asia.202400840","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:00:16Z","timestamp":1728558016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hydrogen Sulfide (H<sub>2<\/sub>S) Activatable Photodynamic Therapy Against Colon Cancer by Tunable FRET Effect"],"prefix":"10.1002","volume":"20","author":[{"given":"Mengting","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxuan","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"},{"name":"Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health Sciences  Shanghai 201318 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering East China University of Science and Technology  Shanghai 200237 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