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By modifying \u03b1\u2010cyano esters into \u03b1\u2010cyano ketones, the synthesis pathway broadens to include a diverse range of 4\u2010CN, 5\u2010amino, and 5\u2010arylamino derivatives of 1,2,3\u2010triazoles, which are achieved notably through the Dimroth rearrangement. This versatility extends further with the potential for a triple cascade reaction, leading to the production of carboximidamide compounds, which are facilitated by the Cornforth rearrangement. Advancements in compound accessibility not only expand the repertoire of synthesized molecules but also open new avenues for potential pharmacological agents.<\/jats:p><jats:p>Building on these findings, we have developed an innovative and efficient method for the divergent synthesis of functionalized 1,2,3\u2010triazoles. This method strategically utilizes \u03b1\u2010cyanocarbonyls and arylazides by harnessing their reactivity and compatibility to orchestrate a variety of molecular transformations. By optimizing these substrates, our goal is to simplify synthetic routes, improve product yields, and accelerate the discovery and development of new chemical entities with promising biological activities.<\/jats:p>","DOI":"10.1002\/asia.202400845","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T11:03:07Z","timestamp":1727780587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Divergent Regioselective Synthesis of Functionalized 1,2,3\u20101<i>H<\/i>\u2010Triazoles from Nitriles and Arylazides Under Metal\u2010Free and\/or Solvent\u2010Free Conditions"],"prefix":"10.1002","volume":"19","author":[{"given":"Fernanda","family":"Petzold Pauli","sequence":"first","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro Instituto de Qu\u00edmica, Departamento de Qu\u00edmica Org\u00e2nica  Rio de Janeiro-RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson","family":"de Oliveira Lima Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense Instituto de Qu\u00edmica, Departamento de Qu\u00edmica Org\u00e2nica  Niter\u00f3i-RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlon","family":"de Almeida Ribeiro Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s Instituto de Qu\u00edmica, Goi\u00e2nia-GO  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Morais Li\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s Instituto de Qu\u00edmica, Goi\u00e2nia-GO  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinicius","family":"Rangel Campos","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense Instituto de Qu\u00edmica, Departamento de Qu\u00edmica Org\u00e2nica  Niter\u00f3i-RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"da Silva Magalh\u00e3es Forezi","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense Instituto de Qu\u00edmica, Departamento de Qu\u00edmica Org\u00e2nica  Niter\u00f3i-RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor","family":"Francisco Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense Faculdade de Farm\u00e1cia, Departamento de Tecnologia Farmac\u00eautica  Niter\u00f3i-RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"de Carvalho da Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense Instituto de Qu\u00edmica, Departamento de Qu\u00edmica Org\u00e2nica  Niter\u00f3i-RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202302849"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28176193"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c06012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202200317"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.07.031"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.01.008"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.12.025"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130357"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112085"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/b616751a"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.06.051"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202200843"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.07.017"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110623"},{"key":"e_1_2_8_15_1","first-page":"572","volume":"32","author":"Dias M. 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