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The approach involves a two\u2010step reaction, utilizing indole derivatives, 2\u2010amino benzyl alcohol, and ninhydrin as key starting materials under mild reaction conditions. The reaction proceeds via a sequential cascade process involving cyclization, condensation and spiro\u2010annulation, leading to the formation of the spirobenzazepinoindole core structure in good to excellent yields. The method offers broad substrate scope, high atom economy, and operational simplicity. The synthesized spirobenzazepinoindoles were fully characterized by spectroscopic techniques, including NMR (\n                    <jats:sup>1<\/jats:sup>\n                    H &amp;\n                    <jats:sup>13<\/jats:sup>\n                    C), IR and mass spectrometry. The methodology provides a valuable tool for the rapid generation of structurally complex spirobenzazepinoindoles, which could serve as scaffolds for the development of new therapeutic agents.\n                  <\/jats:p>","DOI":"10.1002\/asia.202401025","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T01:05:22Z","timestamp":1727053522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Syntheses of Novel Spirobenzazepinoindole Derivatives via Lewis\u2010Acid Catalyzed Pictet\u2010Spengler Cyclization"],"prefix":"10.1002","volume":"19","author":[{"given":"Diksha","family":"Bansal","sequence":"first","affiliation":[{"name":"Organic and Bio-Organic Chemistry laboratory CSIR-Central Leather Research Institute (CSIR-CLRI)  Chennai 600020 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokulprasanth","family":"Nataraj","sequence":"additional","affiliation":[{"name":"Organic and Bio-Organic Chemistry laboratory CSIR-Central Leather Research Institute (CSIR-CLRI)  Chennai 600020 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Sivaganesan","sequence":"additional","affiliation":[{"name":"Organic and Bio-Organic Chemistry laboratory CSIR-Central Leather Research Institute (CSIR-CLRI)  Chennai 600020 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal Kanti","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Karimpur Pannadevi College (KPDC) University of Kalyani, Karimpur  Nadia, West Bengal 741152 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5927-932X","authenticated-orcid":false,"given":"Saikat","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Organic and Bio-Organic Chemistry laboratory CSIR-Central Leather Research Institute (CSIR-CLRI)  Chennai 600020 India"},{"name":"AcSIR-Academy of Scientific and Innovative Research  Ghaziabad, Uttar Pradesh 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105076"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2022.100606"},{"key":"e_1_2_8_4_1","unstructured":"\u00a0"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201300100"},{"key":"e_1_2_8_6_2","doi-asserted-by":"crossref","unstructured":"B.\u2005T. 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