{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:55:41Z","timestamp":1759971341382,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SERB\/CRG\/2020\/005958"],"award-info":[{"award-number":["SERB\/CRG\/2020\/005958"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sn(IV) complex of N\u2010Confused Porphyrin (Sn(IV)\u2010NCP) has been prepared and characterized by several spectroscopic techniques to verify its structure and purity. Sn(IV)\u2010NCP shows a red shift in both the Soret and Q bands compared to the free base NCTPP. The last Q band appears in the NIR region. Based on these characteristics, we investigated the antiproliferative properties and antimicrobial photodynamic therapy (a\u2010PDT) efficiency of Sn(IV)\u2010NCP against the bacteria <jats:italic>Escherichia coli<\/jats:italic> (<jats:italic>E. coli<\/jats:italic>) and <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>S. aureus<\/jats:italic>). Further, we investigated the photodynamic activity of Sn (IV)\u2010NCP against Michigan cancer foundation\u20107 (MCF\u20107) cancer cells, to assess its potential as an effective therapeutic agent. Treated MCF\u20107 cells with the compound show cytotoxic effects as compared to the untreated ones. At a higher concentration (128\u2005\u03bcg\/ml), Sn(IV)\u2010NCP exhibited 90\u2009% inhibition, while at a lower concentration (32\u2005\u03bcg\/ml), it showed 70\u2009% inhibition in MCF\u20107 cells. The IC<jats:sub>50<\/jats:sub> value for this compound against MCF\u20107 cells was found 16.67\u2005\u03bcg\/ml. At 32\u2005\u03bcg\/ml, Sn(IV)\u2010NCP showed only around 4\u2009% cell inhibition, indicating minimal cytotoxic effects on human embryonic kidney cells (HEK293).<\/jats:p>","DOI":"10.1002\/asia.202401027","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T08:04:28Z","timestamp":1731485068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilization of Tin(IV) Complex of N\u2010Confused Porphyrin for Antiproliferative Activity and Antimicrobial Photodynamic Chemotherapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Rajesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee 247667 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Kumar Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering Indian Institute of Technology Roorkee  Roorkee 247667 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramasare","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering Indian Institute of Technology Roorkee  Roorkee 247667 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-3759","authenticated-orcid":false,"given":"Muniappan","family":"Sankar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee 247667 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11131946"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335490712200205"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00549"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S234610"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00016-10"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.4c01222"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0036023622601209"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2020.102156"},{"key":"e_1_2_6_9_1","volume":"2051","author":"Olkhov A. A.","year":"2018","journal-title":"AIP Conf. Proc."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA09343K"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs35531d"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00373D"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.8b00507"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA09343K"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4314\/ejst.v15i2.6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2023.103795"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3DT00603D"},{"key":"e_1_2_6_18_1","first-page":"3","volume":"358","author":"Leimbach A.","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819dc44d"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00081a047"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199407791"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NJ00112D"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT03296D"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm300009q"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.201800630"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200602481"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/photochem3030019"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2023.103815"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol9910114"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200602481"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2019.01.025"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202401027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T13:26:32Z","timestamp":1759929992000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.202401027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,17]]}},"alternative-id":["10.1002\/asia.202401027"],"URL":"https:\/\/doi.org\/10.1002\/asia.202401027","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"type":"print","value":"1861-4728"},{"type":"electronic","value":"1861-471X"}],"subject":[],"published":{"date-parts":[[2024,12,4]]},"assertion":[{"value":"2024-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401027"}}