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Herein, we report on the self\u2010assembled lipid nanoparticles (LNPs) of two new pegylated lipopeptides for killing TNBCs (MDA\u2010MB\u2010231). The pegylated lipopeptides were synthesized by conjugating an n\u2010hexadecyl hydrophobic tail to one end of a (PEG)<jats:sub>27<\/jats:sub> unit the other distal end of which was covalently grafted with two previously reported tumor targeting RGDK\u2010 and CGKRK\u2010 peptides. The SEM images of the self\u2010assembled LNPs formed upon dissolution of the pegylated lipopeptides in aqueous medium revealed formation of spherical aggregates. The degree of cellular uptake for the self\u2010assembled LNPs formed by the pegylated CGKRK\u2010lipopeptide were found to be significantly higher than that for the self\u2010assembled LNPs formed by the pegylated RGDK\u2010lipopeptide in MCF\u20107, MDA\u2010MB\u2010231, HEK\u2010293 and HFF cells. Notably, about 60\u2009% TNBCs (MDA\u2010MB\u2010231 cells) were killed upon treatment with commercially available potent JAK2 inhibitor (WP 1066) loaded LNPs of the pegylated RGDK\u2010lipopeptide. Contrastingly, the same treatment killed only about 20\u2009% non\u2010cancerous HEK\u2010293 cells. The self\u2010assembled pegylated LNPs described herein open the door for undertaking <jats:italic>preclinical<\/jats:italic> studies in animal models for TNBCs.<\/jats:p>","DOI":"10.1002\/asia.202401049","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T09:34:14Z","timestamp":1730108054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010assembled Lipid Nanoparticles for Killing Triple Negative Breast Cancer Cells"],"prefix":"10.1002","volume":"20","author":[{"given":"Wahida","family":"Rahaman","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences Indian Institute of Science Education and Research Kolkata  Mohanpur, Nadia, West Bengal 741246 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0734-8320","authenticated-orcid":false,"given":"Arabinda","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences Indian Institute of Science Education and Research Kolkata  Mohanpur, Nadia, West Bengal 741246 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174287"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v13.i3.209"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v8.i2.120"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57152"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00227"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01341-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00565-2"},{"key":"e_1_2_10_9_1","first-page":"106","volume":"12","author":"Wahba H. 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