{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:59:49Z","timestamp":1793289589966,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006593","name":"Board of Research in Nuclear Sciences","doi-asserted-by":"publisher","award":["58\/14\/15\/2023-BRNS\/12127"],"award-info":[{"award-number":["58\/14\/15\/2023-BRNS\/12127"]}],"id":[{"id":"10.13039\/501100006593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Herein, we have reported a series of cationic aggregation\u2010induced emission (AIE) active iridium(III) complexes (\n                    <jats:bold>Ir1\u2010Ir5<\/jats:bold>\n                    ) of the type [Ir(C\u2009N)\n                    <jats:sub>2<\/jats:sub>\n                    (N\u2009N)]Cl, wherein C\u2009N is a cyclometalating 2\u2010phenylbenzimidazole ligand with varying alkyl chain lengths and N\u2009N is a 2,2\u2019\u2010bipyridine ligand attached to bis\u2010polyethylene glycol chains, for the treatment of bacterial infections. The AIE phenomenon of the complexes leveraged for detecting bacteria by fluorescence microscopy imaging that displayed a strong red emission in Gram\u2010positive bacteria. The antibacterial activity of the complexes assessed against Gram\u2010positive methicillin\u2010sensitive\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ,\n                    <jats:italic>E. faecium<\/jats:italic>\n                    and\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    and Gram\u2010negative\n                    <jats:italic>E. coli<\/jats:italic>\n                    and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    bacteria of clinical interest. The complexes\n                    <jats:bold>Ir2\u2010Ir4<\/jats:bold>\n                    exerted potent antibacterial activity towards Gram\u2010positive strains with low minimum inhibitory concentrations (MICs) values in the range of 1\u20139\u2005\u03bcM, which is comparable to clinically approved antibiotic vancomycin. In contrast, these complexes were found to be inactive towards Gram\u2010negative bacterial strains (MICs &gt;100\u2005\u03bcM). The mechanism of antibacterial activity of the complexes implies that ROS generation, membrane depolarization and rupture are responsible for bacterial cell death. Further, the complexes\n                    <jats:bold>Ir1\u2010Ir3<\/jats:bold>\n                    were found to be low\u2010toxic against human red blood cells and human embryonic kidney (HEK293) cells, indicating their potential for use as antibacterial agents.\n                  <\/jats:p>","DOI":"10.1002\/asia.202401060","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T03:53:50Z","timestamp":1731124430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Development of Cyclometalated Iridium(III) Complexes of 2\u2010Phenylbenzimidazole and Bipyridine Ligands for Selective Elimination of Gram\u2010Positive Bacteria"],"prefix":"10.1002","volume":"20","author":[{"given":"Aryan","family":"Gautam","sequence":"first","affiliation":[{"name":"School of Physical Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gupta","sequence":"additional","affiliation":[{"name":"School of Physical Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Prasad","sequence":"additional","affiliation":[{"name":"Amity Institute of Click Chemistry Research and Studies Amity University  Noida, Uttar Pradesh 201303 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-1269","authenticated-orcid":false,"given":"Pijus K.","family":"Sasmal","sequence":"additional","affiliation":[{"name":"School of Physical Sciences Jawaharlal Nehru University  New Delhi 110067 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,23]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC06037B"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10101310"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"C. 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Khorana S. Khusuwan N. Kissoon E. Kobeissi T. Kostyanev F. Krapp R. Krumkamp A. Kumar H. H. Kyu C. Lim K. Lim D. Limmathurotsakul M. J. Loftus M. Lunn J. Ma A. Manoharan F. Marks J. May M. Mayxay N. Mturi T. Munera-Huertas P. Musicha L. A. Musila M. M. Mussi-Pinhata R. N. Naidu T. Nakamura R. Nanavati S. Nangia P. Newton C. Ngoun A. Novotney D. Nwakanma C. W. Obiero T. J. Ochoa A. Olivas-Martinez P. Olliaro E. Ooko E. Ortiz-Brizuela P. Ounchanum G. D. Pak J. L. Paredes A. Y. Peleg C. Perrone T. Phe K. Phommasone N. Plakkal A. Ponce-de-Leon M. Raad T. Ramdin S. Rattanavong A. Riddell T. Roberts J. V. Robotham A. Roca V. D. Rosenthal K. E. Rudd N. Russell H. S. Sader W. Saengchan J. Schnall J. A. G. Scott S. Seekaew M. Sharland M. Shivamallappa J. Sifuentes-Osornio A. J. Simpson N. Steenkeste A. J. Stewardson T. Stoeva N. Tasak A. Thaiprakong G. Thwaites C. Tigoi C. Turner P. Turner H. R. van Doorn S. Velaphi A. Vongpradith M. Vongsouvath H. Vu T. Walsh J. L. Walson S. Waner T. Wangrangsimakul P. Wannapinij T. Wozniak T. E. M. W. Young Sharma K. C. Yu P. Zheng B. Sartorius A. D. Lopez A. Stergachis C. Moore C. Dolecek M. Naghavi Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet2022 399 629\u2013655.","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_2_8_4_1","unstructured":"T. Coque D. Graham A. Pruden A. So E. Topp Bracing for Superbugs: Strengthening environmental action in the One Health response to antimicrobial resistance United Nations Environment Programme Technical report 2023."},{"key":"e_1_2_8_5_1","first-page":"1","volume":"20","author":"O'Neill J.","year":"2014","journal-title":"Antimicrobial resistance: Tackling a crisis for the health and wealth of nations, Rev. Antimicrob. 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