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Polymers, either synthetic or natural, or even a combination of the two, can be used to create injectable hydrogels. Clinically approved injectable hydrogels are being used as dressings for burn wounds, bone and cartilage reconstruction. Injectable hydrogels have recently gained tremendous attention for their delivery into the liver in pre\u2010clinical models. However, their efficacy in clinical studies remains yet to be established. In this article, we describe principles for the design of these injectable hydrogels, delivery strategies and their potential applications in facilitating liver regeneration and ameliorating injury. We also discuss the several constraints related to translation of these hydrogels into clinical settings for liver diseases and deliberate some potential solutions to combat these challenges.<\/jats:p>","DOI":"10.1002\/asia.202401106","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T01:54:55Z","timestamp":1731894895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Injectable Hydrogels for Liver: Potential for Clinical Translation"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5310-8662","authenticated-orcid":false,"given":"Ashwini","family":"Vasudevan","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Medicine Institute of Liver and Biliary Sciences  New Delhi 110070 India"},{"name":"Amity Institute of Biotechnology Amity University Uttar Pradesh  Sector-125 Noida 201301 Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doyel","family":"Ghosal","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Engineering Indian Institute of Technology  New Delhi 110016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sita","family":"Ram Sahu","sequence":"additional","affiliation":[{"name":"School of Interdisciplinary Research Indian Institute of Technology  New Delhi 110016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narsing","family":"Kumar Jha","sequence":"additional","affiliation":[{"name":"Department of Applied Mechanics Indian Institute of Technology  New Delhi 110016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Vijayaraghavan","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology Amity University Uttar Pradesh  Sector-125 Noida 201301 Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Engineering Indian Institute of Technology  New Delhi 110016 India"},{"name":"Department of Biomedical Engineering All India Institute of Medical Sciences  New Delhi 110029 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-2772","authenticated-orcid":false,"given":"Savneet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Medicine Institute of Liver and Biliary Sciences  New Delhi 110070 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"crossref","unstructured":"M.\u2005R. 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