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This sensing platform employs a fluorescence\u2010based ligand displacement approach, featuring a <jats:italic>meso<\/jats:italic>\u2010(<jats:italic>N<\/jats:italic>\u2019\u2010acetyl\u2010hydrizide)\u2010based BODIPY derivative (<jats:bold>1<\/jats:bold>) complexed with Cu<jats:sup>2+<\/jats:sup>. Initially highly fluorescent, compound <jats:bold>1<\/jats:bold> is selectively quenched by Cu<jats:sup>2+<\/jats:sup> ions, forming the <jats:bold>1\u2010Cu<jats:sup>2+<\/jats:sup><\/jats:bold> complex. The high affinity between His and Cu<jats:sup>2+<\/jats:sup> effectively displaces <jats:bold>1<\/jats:bold> from the complex, restoring fluorescence. The system exhibits rapid response (within 5\u2005minutes), excellent sensitivity (detection limit of 78\u2005nM), operational simplicity, and a large fluorescence \u201cturn\u2010on\u201d signal. It demonstrates remarkable selectivity for His over other amino acids, with maleimide masking cysteine interference. Notably stable in complex biological matrices, the sensor has successfully quantified His in artificial urine samples. Its practical applicability extends to paper\u2010based test strips, offering portability and potential for real\u2010time His monitoring in clinical diagnostics and biological systems.<\/jats:p>","DOI":"10.1002\/asia.202401182","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T07:25:27Z","timestamp":1731137127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Copper\u2010Incorporated <i>meso<\/i>\u2010(<i>N\u2019<\/i>\u2010acetyl\u2010hydrizide)\u2010BODIPY as a \u201cOff\u2010On\u201d Fluorescent Probe for Histidine"],"prefix":"10.1002","volume":"20","author":[{"given":"Siyoung","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University  26 Kyungheedae-ro Dongdaemun-gu, Seoul 02447 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University  26 Kyungheedae-ro Dongdaemun-gu, Seoul 02447 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizki Rachmad","family":"Saputra","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University  26 Kyungheedae-ro Dongdaemun-gu, Seoul 02447 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-8342","authenticated-orcid":false,"given":"Youngmi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Research Institute of Basic Sciences Kyung Hee University  26 Kyungheedae-ro Dongdaemun-gu, Seoul 02447 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1172\/JCI108016","volume":"55","author":"Kopple J. 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