{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:52:44Z","timestamp":1790909564660,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22367023, 82072309"],"award-info":[{"award-number":["22367023, 82072309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Pomacea canaliculata<\/jats:italic> is an invasive species that poses significant threats to agriculture and human health. The development of environmentally friendly molluscicides is crucial for its management. In this study, we synthesized 17 fluoropyridylphenylurea derivatives using a halogen modulation strategy to explore their potential as molluscicides. Compounds <jats:bold>L\u20101<\/jats:bold> and <jats:bold>L\u20102<\/jats:bold> demonstrated notable molluscicidal activity, with LC<jats:sub>50<\/jats:sub> values of 1.377\u2005mg\/L and 1.001\u2005mg\/L, respectively. Among these, <jats:bold>L\u20102<\/jats:bold> exhibited superior efficacy while causing minimal harm to other aquatic organisms, particularly fish. The molluscicidal mechanism of <jats:bold>L\u20102<\/jats:bold> was investigated using Tandem Mass Tags (TMT)\u2010labeled quantitative proteomic analysis and non\u2010targeted metabolic analysis. These analyses revealed that <jats:bold>L\u20102<\/jats:bold> significantly affected the liver metabolism of <jats:italic>P. canaliculata<\/jats:italic> by disrupting the transaminase, gluconeogenesis, and glycolysis pathways. This metabolic disruption is likely a contributing factor to the mortality observed in the snails. Our findings suggest that compound <jats:bold>L\u20102<\/jats:bold> is a promising molluscicide, offering high efficiency and minimal environmental impact. These insights could guide future research and development in molluscicide applications.<\/jats:p>","DOI":"10.1002\/asia.202401374","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T06:05:36Z","timestamp":1739253936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Halogen Modulation: Novel Fluoropyridylphenylurea Derivatives as Potent Molluscicides Unveiling Snail\u2010Killing Mechanisms"],"prefix":"10.1002","volume":"20","author":[{"given":"Jinsong","family":"Liang","sequence":"first","affiliation":[{"name":"School of Chemical Science and Technology Yunnan Characteristic Plant Extraction Laboratory Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province Yunnan University  Kunming 650091 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxun","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Technology Yunnan Characteristic Plant Extraction Laboratory Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province Yunnan University  Kunming 650091 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisi","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Technology Yunnan Characteristic Plant Extraction Laboratory Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province Yunnan University  Kunming 650091 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Technology Yunnan Characteristic Plant Extraction Laboratory Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province Yunnan University  Kunming 650091 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Duan","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention  Shanghai 200025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1782-5626","authenticated-orcid":false,"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Technology Yunnan Characteristic Plant Extraction Laboratory Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province Yunnan University  Kunming 650091 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"443","volume":"25","author":"Naylor R.","year":"1996","journal-title":"Ambio"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09670879409371882"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182016000652"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1328-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30434-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(82)90064-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/eesa.2000.1924"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-017-0246-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01539-15"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-018-2868-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c07847"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01788"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2022.105243"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115272"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.12.029"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118673"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2004.12.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2010.11.005"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/eesa.1996.0109"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2007.07.010"},{"key":"e_1_2_7_21_1","first-page":"133","volume":"16","author":"Bakry F. A.","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713498457"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.202401374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:21:48Z","timestamp":1759944108000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.202401374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,11]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4,3]]}},"alternative-id":["10.1002\/asia.202401374"],"URL":"https:\/\/doi.org\/10.1002\/asia.202401374","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,11]]},"assertion":[{"value":"2024-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202401374"}}