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For more than a decade, nanozymes have shown astonishingly enhanced enzymatic activity as compared to its naturally occurring counterpart and emerged as a potential platform in biomedical science. The current study reports a novel flower shaped gold\u2010iron oxide nanocomposite prepared via a facile and green solution phase redox mediated synthesis. The precursor gold salt conversion to nanometallic Au(0) is mediated by iron metal powder, which acts both as reductant and metal source in the resultant gold nanoparticle decorated iron oxide nanocomposite. Calcination of the synthesized nanocomposites leads to morphological evolution into unique flower shape with improved homogeneity between gold and iron components along with metal surface exposure. The gold\u2010iron oxide nanocomposites have been utilized first time for peroxidase mimicking study and exhibit enhanced catalytic activity at 25\u2009\u00b0C with low Michaelis\u2010Menten constant (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>m<\/jats:sub>\n                    ) and higher maximum reaction velocity (\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    ) as compared to the natural enzyme Horseradish peroxidase (HRP). In addition, combined assembly of this nanozyme with natural enzyme glucose oxidase also serves a potential platform for the visible colorimetric detection and quantification of glucose with limit of detection (LOD) of 15\u2005\u03bcM.\n                  <\/jats:p>","DOI":"10.1002\/asia.202401479","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:19:52Z","timestamp":1734956392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dual Activities of Flower\u2010Like Gold\u2010Iron Oxide Nanozyme for Peroxidase\u2010Mimicking and Glucose Detection"],"prefix":"10.1002","volume":"20","author":[{"given":"Kanika","family":"Bharti","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee 247 667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sancharika","family":"Dalal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee 247 667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avni","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee 247 667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5891-951X","authenticated-orcid":false,"given":"Kalyan","family":"K. 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