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Mechanistic studies suggested that\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(hydroxymethyl)\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methylacetamide generated\n                    <jats:italic>in\u2005situ<\/jats:italic>\n                    from DMA\/H\n                    <jats:sub>2<\/jats:sub>\n                    O under electrochemical conditions serves as a formaldehyde surrogate. The developed methodology features mild, base\u2010 and metal catalyst\u2010free conditions. The reaction can accommodate a broad range of substrate scopes and offers an alternative route to access a series of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010hydroxymethylated indole,\n                    <jats:italic>bis<\/jats:italic>\n                    \u2010indole, carbazole, and indazole derivatives. A gram\u2010scale synthesis was demonstrated to show the scaled\u2010up applicability of this transformation.\n                  <\/jats:p>","DOI":"10.1002\/asia.202401489","type":"journal-article","created":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T22:13:52Z","timestamp":1735856032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Electrochemically Driven Site\u2010Selective\n                    <i>N<\/i>\n                    \u2010Hydroxymethylation of Indoles and Derivatives"],"prefix":"10.1002","volume":"20","author":[{"given":"Thanathip","family":"Chomphunuch","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Science Mahidol University  Rama VI Road Bangkok 10400 Thailand"},{"name":"Center of Excellence for Innovation in Chemistry (PERCH-CIC) Faculty of Science Mahidol University  Rama VI Road Bangkok 10400 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