{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:10:53Z","timestamp":1784873453665,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020512","name":"Indian Institute of Science Education and Research Thiruvananthapuram","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,4,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A one\u2010pot methodology for the tandem acylation and oxidative aromatization of vinylogous thioesters to 2\u2010acyl\u20105\u2010(alkyl\/arylthio) phenols is presented. Initially, cyclohexane\u20101,3\u2010diones were converted to vinylogous thioesters through FeCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010mediated thioenolization. This was followed by LiTMP\u2010mediated acylation and DDQ\u2010mediated aromatization, which resulted in the synthesis of sulphur derived oxybenzone analogs. Notably, replacing the methoxy group of oxybenzone with alkylthioxy or arylthioxy groups significantly enhanced UV absorption properties. The newly synthesized oxybenzone analogs exhibited superior UV absorption, effectively covering the entire UVA and UVB regions spanning from 240 to 440\u2005nm. Furthermore, toxicity studies conducted on HEK293T cells demonstrated that many of the thio\u2010analogs exhibit lower toxicity compared to parent oxybenzone, suggests potential for safer and more effective UV protection formulas.\n                  <\/jats:p>","DOI":"10.1002\/asia.202401526","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T10:38:37Z","timestamp":1736764717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Non\u2010Benzenoid Route to Thio\u2010Oxybenzone Analogs: Superior UV Protection with Reduced Cytotoxicity"],"prefix":"10.1002","volume":"20","author":[{"given":"S.","family":"Keerthana","sequence":"first","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research  Thiruvananthapuram Kerala 695551 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Indora","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research  Thiruvananthapuram Kerala 695551 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Kumari","sequence":"additional","affiliation":[{"name":"School of Biology Indian Institute of Science Education and Research  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nongmaithem","family":"Sadananda Singh","sequence":"additional","affiliation":[{"name":"School of Biology Indian Institute of Science Education and Research  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3742-319X","authenticated-orcid":false,"given":"Rajendar","family":"Goreti","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research  Thiruvananthapuram Kerala 695551 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"e_1_2_8_1_1","author":"Roky A. 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Sowbarnika G. Rajendar Photoprotective Oxybenzone analogs and preparation thereof. Indian Patent Filed 2024 202441034878."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12084311"},{"key":"e_1_2_8_19_1","unstructured":"R. Li S. Sebti Y. Liu Y. Qin H. Song C. Cheng C. (2018) U.S. Patent No. 9 868 747filed 18 February 2015 issued 16 January 2018."},{"key":"e_1_2_8_20_1","unstructured":"Y. Makabe Y. Okuyama 2012 U. S. 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