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This study presents a novel metal\u2010organic framework (MOF), Cu\u2010AIPA, formulated as Cu(AIPA)(DMF)<jats:sub>2<\/jats:sub> (AIPA: 2\u2010amino isophthalic acid, DMF: <jats:italic>N<\/jats:italic>, <jats:italic>N<\/jats:italic>\u2010dimethylformamide). The Cu\u2010AIPA framework integrates three distinct catalytic mechanisms: redox activity, Br\u00f8nsted basicity, and Lewis acidity. The structure of Cu\u2010AIPA features redox\u2010active Cu(II) centers and Br\u00f8nsted basic sites, enabling the sequential transformation of alcohols to aldehydes and their subsequent condensation into imines. The close spatial arrangement of these redox\u2010active\/Lewis acidic and basic sites within the confined pores of Cu\u2010AIPA facilitates efficient tandem catalysis. This process involves oxidizing benzyl alcohol to benzaldehyde using TEMPO without requiring an external base, followed by amine condensation. Compared with HKUST\u20101, another Cu\u2010based MOF with a high surface area, Cu\u2010AIPA demonstrated superior catalytic performance at room temperature. Recyclability tests revealed that Cu\u2010AIPA retained over 90\u2009% conversion efficiency across at least three catalytic cycles. This study highlights the potential of MOFs incorporating multiple catalytic sites and confined pore structures for tandem reactions, emphasizing their potential for scalable and sustainable industrial applications.<\/jats:p>","DOI":"10.1002\/asia.202401614","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T22:28:53Z","timestamp":1738708133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oxidation\u2010Condensation Tandem Catalysis <i>via<\/i> a Multifunctional Cu\u2010Based Metal\u2010Organic Framework"],"prefix":"10.1002","volume":"20","author":[{"given":"Hyeonsu","family":"Kim","sequence":"first","affiliation":[{"name":"KNU G-LAMP Research Center KNU Institute of Basic Sciences and Department of Chemistry Kyungpook National University  Daegu 41566 Republic of Korea"},{"name":"Center for Bio-based Chemistry Korea Research Institute of Chemical Technology (KRICT)  Ulsan 44429 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younghu","family":"Son","sequence":"additional","affiliation":[{"name":"KNU G-LAMP Research Center KNU Institute of Basic Sciences and Department of Chemistry Kyungpook National University  Daegu 41566 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dogyeong","family":"Hwang","sequence":"additional","affiliation":[{"name":"KNU G-LAMP Research Center KNU Institute of Basic Sciences and Department of Chemistry Kyungpook National University  Daegu 41566 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purna Chandra","family":"Rao","sequence":"additional","affiliation":[{"name":"KNU G-LAMP Research Center KNU Institute of Basic Sciences and Department of Chemistry Kyungpook National University  Daegu 41566 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Younghoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Bio-based Chemistry Korea Research Institute of Chemical Technology (KRICT)  Ulsan 44429 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7436-6273","authenticated-orcid":false,"given":"Minyoung","family":"Yoon","sequence":"additional","affiliation":[{"name":"KNU G-LAMP Research Center KNU Institute of Basic Sciences and Department of Chemistry Kyungpook National University  Daegu 41566 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201410738"},{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"G. 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