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In this study, novel dipicolylamino derivatives of fluorene and fluorenone were synthesized via Sonogashira cross\u2010coupling reactions with high yields. These compounds demonstrated exceptional selectivity for fluorescence turn\u2010off by Cu(II) ions, with detection limits of 0.99\u2005\u03bcM and 1.11\u2005\u03bcM in a DMSO\u2010HEPES buffer system. Investigations using Job's plot, fluorescence recovery with EDTA, and mass spectrometry revealed that the sensing mechanism involves complexation between the compounds and Cu(II) ions. Notably, the Cu(II)\u2010fluorene complex exhibited a selective fluorescence turn\u2010on response to glyphosate, achieving a detection limit of 0.93\u2005\u03bcM. Quantitative analysis in real water samples demonstrated good recovery rates, underscoring the practical utility of these fluorene and fluorenone derivatives in environmental monitoring.<\/jats:p>","DOI":"10.1002\/asia.202401622","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T15:43:31Z","timestamp":1738856611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dipicolylaminofluorene Derivatives for Fluorescent Sensing of Copper(II) Ion and Glyphosate"],"prefix":"10.1002","volume":"20","author":[{"given":"Komthep","family":"Silpcharu","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Science Chulalongkorn University  11th floor MHMK Building, Pathumwan District Bangkok 10330 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9902-259X","authenticated-orcid":false,"given":"Quynh","family":"Nguyen 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