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Prospective approach for its solution is based on the development of new and improved pharmacological principles, including the use of allosteric inhibitors of biomacromolecules and the generation of those unfolded or misfolded. Allosteric sites as hosts can be sterically blocked by rigid 3D\u2010shaped effectors as guests. Because host bioreceptors recognize only their external surface, the nature of abiotic and artificial 3D\u2010molecular platforms plays no important role in the supramolecular host\u2013guest binding. Another of their <jats:italic>modus operandi<\/jats:italic> is based on blocking a surface of supramolecular interactions between biomacromolecules to cause the appearance of misfolded macromolecular assemblies or their disaggregation. 3D\u2010shaped polyhedral inorganic and metallocomplex molecules, the periphery of which is decorated with terminal biorelevant or vector group(s), seem to be promising antitumor and antiviral drug candidates, in the case of which the emergence of drug resistance is not observed.<\/jats:p>","DOI":"10.1002\/asia.202401842","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T05:10:09Z","timestamp":1749532209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Alternative Approach to Avoid Drug Resistance: Polyhedral Inorganic and Metallomacrobicyclic 3D\u2010Shaped Guests Strongly Binding to Allosteric Sites and\/or Macromolecular Interfaces"],"prefix":"10.1002","volume":"20","author":[{"given":"Yan Z.","family":"Voloshin","sequence":"first","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences  31 Leninsky pr. 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