{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:48:43Z","timestamp":1785944923749,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chemically powered colloidal motors exhibit significant potential for applications in oral cleaning and antimicrobial treatment. The integration of MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010based colloidal motors with common mouth\u2010rinsing H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    solutions for sterilization and disinfection via reactive oxygen species (ROS) represents an ideal approach. In this study, we fabricate uniform dumbbell\u2010shaped (DS\u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010motor), spherical (S\u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010motor), and silver half\u2010coated spherical Janus Ag\u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    colloidal motors (JS\u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010motor) using hydrothermal, co\u2010precipitation, and sputtering methods, respectively. These motors are propelled by O\n                    <jats:sub>2<\/jats:sub>\n                    bubble ejection generated from the catalytic decomposition of low\u2010concentration H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    by peroxidase\u2010like MnO\n                    <jats:sub>2<\/jats:sub>\n                    components. Notably, the JS\u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010motors achieve a maximum speed of 146.4\u00a0\u00b5m\u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    in gargle containing 1.5% H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . In vitro and in vivo antimicrobial trials demonstrated that the JS\u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010motor gargle exhibits superior sterilization rates of 98.1% and 97.4% against both planktonic and biofilm\u2010forming\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    and\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    . Consequently, it significantly enhances the therapeutic efficacy in treating periodontitis in Wistar rats, as evidenced by a marked reduction in inflammatory cells. The mechanical force exerted by these colloidal motors, along with cation adhesion to bacterial membranes and the antimicrobial effects of ROS, collectively contribute to this enhanced performance. Our findings introduce a novel strategy for the treatment of chronic inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1002\/asia.202500157","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T09:13:02Z","timestamp":1744189982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Self\u2010Propelled MnO\n                    <sub>2<\/sub>\n                    \u2010Based Colloidal Motors for Active Treatment of Periodontal Inflammation"],"prefix":"10.1002","volume":"20","author":[{"given":"Miaomiao","family":"Huang","sequence":"first","affiliation":[{"name":"School of Medicine and Health Harbin Institute of Technology  Harbin 150080 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changcheng","family":"Ke","sequence":"additional","affiliation":[{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou 325000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou 325000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narisu","family":"Hu","sequence":"additional","affiliation":[{"name":"Affiliated Hosp 2 Oral Implant Ctr Harbin Medical University  Harbin Heilongjiang 150086 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Harbin Institute of Technology  Harbin 150080 P. R. China"},{"name":"Key Laboratory of Science and Engineering for the Multi\u2010modal Prevention and Control of Major Chronic Diseases Ministry of Industry and Information Technology HIT Zhengzhou Research Institute  Zhengzhou 450000 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"He","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Harbin Institute of Technology  Harbin 150080 P. R. China"},{"name":"Key Laboratory of Science and Engineering for the Multi\u2010modal Prevention and Control of Major Chronic Diseases Ministry of Industry and Information Technology HIT Zhengzhou Research Institute  Zhengzhou 450000 P. R. 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