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Despite being one of the most commonly conducted reactions by researchers in both academia and industry, the synthesis of amides remains a staple in chemical research and development. Transamidation reactions enable the one\u2010pot conversion of one type of amide into another. Additionally, this process is crucial in the complete synthesis of specific naturally\u2010occurring compounds. However, these methods have certain limitations such as using toxic and corrosive starting materials, usage of strong acid or base, and metal mediated reaction, which can lead to excessive hydrolysis of the desired amide product. To overcome these challenges, more practical and efficient approaches have been developed. Metal\u2010free transamidation reactions have emerged as a powerful and versatile synthetic methodology in organic chemistry, allowing for the direct conversion of amides into new amide products without relying on metal catalysts. In the review article, we have focused on various metal\u2010free transamidation protocols of unactivated amides.<\/jats:p>","DOI":"10.1002\/asia.202500327","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T05:49:20Z","timestamp":1741931360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Advances in Metal\u2010Free Transamidation: A Sustainable Approach to Amide Bond Formation"],"prefix":"10.1002","volume":"20","author":[{"given":"Niharan","family":"Sivaraj","sequence":"first","affiliation":[{"name":"Chemistry Division School of Advanced Sciences Vellore Institute of Technology  Chennai Campus Chennai Tamil Nadu 600127 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Dohi","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Ritsumeikan University  1\u20101\u20101 Nojihigashi Kusatsu Shiga 525\u20100058 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fateh V.","family":"Singh","sequence":"additional","affiliation":[{"name":"Chemistry Division School of Advanced Sciences Vellore Institute of Technology  Chennai Campus Chennai Tamil Nadu 600127 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_11_1_1","volume-title":"The Amide Linkage: Structural Significance in Chemistry, Biochemistry, and Materials Science","author":"Greenberg A.","year":"2000"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04842"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10702"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm200187y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01409"},{"key":"e_1_2_11_6_1","volume-title":"Amino Acids, Peptides, and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry","author":"Hughes A. 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