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The compounds were isolated as single crystals and characterized by spectroscopic and microanalytical techniques. Owing to the bioavailability and biocompatibility of copper, the oxidative DNA cleavage ability of\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    was studied by incubating supercoiled (SC) pUC19 DNA (40 \u00b5M). The highest cleavage efficiency of complex\n                    <jats:bold>3<\/jats:bold>\n                    is attributed to the strong partial intercalation of 1, 10\u2010phenanthroline rings, which enhances reactive oxygen species (ROS) generation. Encapsulation of\n                    <jats:bold>3<\/jats:bold>\n                    in a polydiacetylene\u2010supported liposome nanocarrier\n                    <jats:bold>(Lip\u2010(3))<\/jats:bold>\n                    improves biocompatibility and anticancer activity while addressing solubility and toxicity concerns. The spherical nanoparticles (\u223c93\u00a0nm), characterized by UV\u2013vis, TEM, DLS, and EDX studies exhibit stability, efficient encapsulation, and suitability for targeted drug delivery.\n                  <\/jats:p>","DOI":"10.1002\/asia.202500421","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:41:25Z","timestamp":1745408485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mononuclear Copper(II) Phosphinates Bearing Mono\u2010, Bi\u2010, and Tridentate\n                    <i>N<\/i>\n                    \u2010Donor Ligands: DNA Binding and Cleavage, Cytotoxicity, and Nanoencapsulation"],"prefix":"10.1002","volume":"20","author":[{"given":"Navneet","family":"Matharoo","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Bombay  Powai Mumbai 400076 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chezhiyan","family":"Sumithaa","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Bombay  Powai Mumbai 400076 India"},{"name":"Department of Chemistry SRM Institute of Science and Technology  Kattankulathur Tamil Nadu 603203 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-3734","authenticated-orcid":false,"given":"Mani","family":"Ganeshpandian","sequence":"additional","affiliation":[{"name":"Department of Chemistry SRM Institute of Science and Technology  Kattankulathur Tamil Nadu 603203 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-3225","authenticated-orcid":false,"given":"Ramaswamy","family":"Murugavel","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Bombay  Powai Mumbai 400076 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2021.03.006"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116211"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27207066"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2020.111070"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2023.102276"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.137366"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpt.2023.05.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c01340"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215579"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2021.04.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114992"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NJ03445C"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja2052599"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3DT00368J"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27123676"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3DT52978A"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2023.116534"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics11100389"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12039-018-1422-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7DT02763J"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4DT03879G"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107634"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.135751"},{"key":"e_1_2_9_24_1","first-page":"1","volume":"38","author":"Yadav A.","year":"2024","journal-title":"Appl Organomet Cem."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031820"},{"key":"e_1_2_9_26_1","first-page":"2409","volume":"14","author":"Demir B. 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