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This study presents a bifunctional imidazole\u2010functionalized Hf(IV)\u2010based metal\u2013organic framework (MOF), <jats:bold>1<\/jats:bold> as a heterogeneous catalyst for synthesizing 1,4\u2010dihydropyridines (1,4\u2010DHPs), which are key moieties in the synthesis of drugs used for cardiovascular treatments. The solvent\u2010free activated form of <jats:bold>1<\/jats:bold>, labeled as <jats:bold>1\u2032<\/jats:bold> catalyzes both Biginelli and Hantzsch reactions under mild conditions. The Biginelli reaction using aldehyde, ethyl acetoacetate, and urea proceeded at 80\u00a0\u00b0C in 0.5\u00a0h with a 99% yield, while the Hantzsch reaction with aldehyde, ethyl acetoacetate, and ammonium acetate occurred at room temperature in ethanol within 1\u00a0h, also achieving a 99% yield. Compound <jats:bold>1\u2032<\/jats:bold> showed broad substrate compatibility in both reactions. Additionally, the MOF exhibited excellent sensing ability for the anticancer drug raloxifene (RLX), showing a fast turn\u2010off fluorescence response (within 5\u00a0s), a low detection limit (9\u00a0nM), and a high Stern\u2013Volmer constant (K<jats:italic><jats:sub>sv<\/jats:sub><\/jats:italic>, 2\u00a0\u00d7\u00a010<jats:sup>6<\/jats:sup>\u00a0M\u207b\u00b9), enabling sensitive detection in diverse environments, including wastewater and biofluids. Detailed investigations into catalytic mechanisms and detection capabilities provide valuable insights for advancing drug synthesis and analytical methodologies. The study provides valuable insights into both the catalytic and sensing capabilities of <jats:bold>1\u2032<\/jats:bold>, demonstrating its potential for advanced pharmaceutical synthesis and real\u2010time drug monitoring.<\/jats:p>","DOI":"10.1002\/asia.202500446","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T09:04:46Z","timestamp":1747731886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An Imidazole Functionalized Hf(IV) Metal\u2013Organic Framework for Multi\u2010Component Biginelli and Hantzsch Condensation Reactions and Fluorometric Sensing of Anticancer Drug Raloxifene"],"prefix":"10.1002","volume":"20","author":[{"given":"Sk Sakir","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology  Guwahati Assam 781039 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