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Notably, this study presents the first examples of 1,2\u2010oxazinane\u20103\u2010ylidene sulfonamide. The synthetic utility of this transformation is highlighted by the direct conversion of isoxazolidine\u20103\u2010ylidine sulfonamides into 3\u2010amino isoxazolines and isoxazole derivatives. This strategy was used as a key step in the total synthesis of antibiotic sulfamethoxazole and its analogues.<\/jats:p>","DOI":"10.1002\/asia.202500630","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T16:11:08Z","timestamp":1754064668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cu\u2010Catalyzed Synthesis of Isoxazolidine\/1,2\u2010Oxazinane\u20103\u2010ylidene Sulfonamide from\n                    <i>O<\/i>\n                    \u2010Alkynyl Hydroxylamines: A Route to Sulfamethoxazole Analogues"],"prefix":"10.1002","volume":"20","author":[{"given":"Santosh J.","family":"Gharpure","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Bombay  Powai Mumbai 400076 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranjal C.","family":"Korekar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Bombay  Powai Mumbai 400076 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11458-009-0037-4"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1652-3714"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2024.105794"},{"key":"e_1_2_8_3_1","first-page":"244","volume":"17","author":"Polonovski M.","year":"1915","journal-title":"Bull. 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