{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:29:23Z","timestamp":1771334963387,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A facile one\u2010step, three\u2010component domino reaction has been established for the efficient synthesis of 3,5\u2010disubstituted\u20102,6\u2010dicyanoaniline derivatives, utilizing aldehydes in conjunction with aromatic, cyclic, and acyclic ketones, as well as malononitrile. This methodology employs CoCl\n                    <jats:sub>2<\/jats:sub>\n                    \u00b76H\n                    <jats:sub>2<\/jats:sub>\n                    O as a catalyst specifically for aromatic and acyclic ketones, whereas a metal\u2010free, base\u2010catalyzed approach is applied for cyclic ketones. The reaction proceeds via a sequential mechanism that encompasses Knoevenagel condensation, Michael addition, and nucleophilic cyclization. Conducted at room temperature, this reaction accommodates both aromatic and aliphatic aldehydes, leveraging inexpensive and readily available substrates, thereby obviating the necessity for costly cocatalysts or ligands. It offers simple conditions, shorter reaction times, high yields, and an atom\u2010economical, eco\u2010friendly one\u2010pot approach. It also provides a broad substrate scope of total 21 compounds, including 14 new compounds. The photo\u2010physical properties, assessed via UV\u2013vis and fluorescence spectroscopy, revealed that some compounds showed red\u2010shifted emissions, indicating their potential as fluorescent probes for bioimaging and as dye candidates for optoelectronic applications such as OLEDs. Gram\u2010scale synthesis confirms its industrial relevance, whereas mechanistic studies, including control experiments and Hammett analysis provide insights into the reaction pathway.\n                  <\/jats:p>","DOI":"10.1002\/asia.202500634","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T10:33:01Z","timestamp":1753093981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cobalt\u2010Catalyzed One\u2010Pot Three\u2010Component Cascade Annulation for the Synthesis of Highly Functionalized 3,5\u2010Disubstituted\u20102,6\u2010Dicyanoanilines at Room Temperature"],"prefix":"10.1002","volume":"20","author":[{"given":"Adrija","family":"Majumdar","sequence":"first","affiliation":[{"name":"Department of Chemistry Jadavpur University  Kolkata West Bengal 700032 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subham","family":"Sau","sequence":"additional","affiliation":[{"name":"Department of Chemistry Jadavpur University  Kolkata West Bengal 700032 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunabha","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Chemistry Jadavpur University  Kolkata West Bengal 700032 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr990281x"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)81720-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1218717"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00039a001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr000664r"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00104a001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.05.097"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.5599"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp0529772"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0446247"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm980212v"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.02.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2006.12.029"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2010.02.009"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-7208(95)00104-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00304948.2012.715055"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/b614747j"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(03)00507-6"},{"key":"e_1_2_8_14_3","doi-asserted-by":"publisher","DOI":"10.1039\/b921390b"},{"key":"e_1_2_8_14_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2010.11.067"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202200230"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.201500242"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201900906"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0ob00089b"},{"key":"e_1_2_8_18_2","first-page":"153","volume":"5","author":"Safaei\u2010Ghomi J.","year":"2015","journal-title":"JNS"},{"key":"e_1_2_8_18_3","doi-asserted-by":"publisher","DOI":"10.1021\/jo047823h"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(94)00937-P"},{"key":"e_1_2_8_20_1","first-page":"37","volume":"35","author":"Keshwal B. 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