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Unique characteristic features of rhodamine moiety have attracted the attention of the researchers currently. In this review article we have discussed rhodamine\u2010based derivatives, their metal complexes and the application in the field of cancer biology. Rhodamine containing scaffolds have been shown to exhibit important mitochondria and lysosome targeting property, they can be used as PDT agent. In vitro and in vivo studies have been conducted for several rhodamine\u2010based compounds and their metal complexes and received excellent results. Exploring this less explored field will lead to the development of rhodamine\u2010based photosensitizers for the simultaneous detection and diagnosis process in the field of cancer biology.<\/jats:p>","DOI":"10.1002\/asia.202500771","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:09:36Z","timestamp":1761541776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rhodamine: Promising Theranostic Agent in Cancer Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Rishav","family":"Das","sequence":"first","affiliation":[{"name":"Department of Chemistry School of Advanced Sciences Vellore Institute of Technology  Vellore Tamil Nadu 632014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6162-1517","authenticated-orcid":false,"given":"Sreejani","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Advanced Sciences Vellore Institute of Technology  Vellore Tamil Nadu 632014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1698-4895","authenticated-orcid":false,"given":"Priyankar","family":"Paira","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Advanced Sciences Vellore Institute of Technology  Vellore Tamil Nadu 632014 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-3152","authenticated-orcid":false,"given":"Rinku","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Department of Chemistry Alipurduar University  Alipurduar West Bengal 736122 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,26]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00799A"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(89)90525-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7146897"},{"key":"e_1_2_7_4_1","first-page":"716","volume":"43","author":"Lampidis T. 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