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In a 1:1 methanol\u2010water medium (v\/v), the receptor <jats:bold>L<\/jats:bold> detected Ni<jats:sup>2+<\/jats:sup> with color change from colorless to yellow and Ag<jats:sup>+<\/jats:sup> with <jats:italic>turn\u2010on<\/jats:italic> fluorescence enhancement. UV\u2013vis spectroscopy, fluorescence titration, FTIR and ESI\u2010MS have been used to analyse the response mechanisms of fluorescent <jats:bold>c<\/jats:bold>olorimetric sensing. The colorimetric sensitivity for Ni<jats:sup>2+<\/jats:sup> is 3.0\u00a0\u00d7\u00a010<jats:sup>\u22127<\/jats:sup>\u00a0M and fluorometric sensitivity for Ag<jats:sup>+<\/jats:sup> is 7.2\u00a0\u00d7\u00a010<jats:sup>\u22127<\/jats:sup>\u00a0M; both the values are sufficient below the WHO permissible limits in aqueous solution. From the Job's plot measurements and the ESI\u2010MS spectrum, 2: 1 stoichiometric complexation between <jats:bold>L<\/jats:bold> and Ni<jats:sup>2+<\/jats:sup>\/Ag<jats:sup>+<\/jats:sup> has been established. Receptor <jats:bold>L<\/jats:bold> shows remarkable detection ability in a wide pH range of 4\u20139 and can be successfully applied for the detection and quantification of Ni<jats:sup>2+<\/jats:sup> ions in environmental samples, and Ag<jats:sup>+<\/jats:sup> ions in BSA protein. At the specified doses and incubation times, <jats:bold>L<\/jats:bold> can be used as an anticancer drug and a selective sensor for bio\u2010imaging of Ag<jats:sup>+<\/jats:sup> ion without having any cytotoxic effects.<\/jats:p>","DOI":"10.1002\/asia.202500779","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T10:41:47Z","timestamp":1753094507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Benzil\u2010Dihydrazone Based Bis\u2010Schiff Base Dual\u2010Sensor for Expeditious Colorimetric Detection of Ni<sup>2+<\/sup> and Fluorometric Detection of Ag<sup>+<\/sup>: Environmental and Biological Applications"],"prefix":"10.1002","volume":"20","author":[{"given":"Dishen","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Chemistry Guru Ghasidas Vishwavidyalaya  Bilaspur, (C.G) India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srishti","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Ghasidas Vishwavidyalaya  Bilaspur, (C.G) India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilash","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Ghasidas Vishwavidyalaya  Bilaspur, (C.G) India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanshika","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Ghasidas Vishwavidyalaya  Bilaspur, (C.G) India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devanand","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Guru Ghasidas Vishwavidyalaya  Bilaspur, (C.G) India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sounik","family":"Manna","sequence":"additional","affiliation":[{"name":"Biochemistry Molecular Endocrinology and Reproductive Physiology Laboratory Department of Human Physiology Vidyasagar University  Midnapore, (W.B.) 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