{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:03:12Z","timestamp":1783472592557,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Horse spleen apoferritin is a highly efficient nanocarrier for encapsulating and delivering metallodrugs, resulting in enhanced stability and therapeutic effectiveness. Herein, Horse spleen apoferritin nanocage(\n                    <jats:bold>Aftn<\/jats:bold>\n                    ) is used to encapsulate the model organoruthenium complex bearing a pyrazolyl\u2013pyridine ligand (\n                    <jats:bold>Ru(bpy)<\/jats:bold>\n                    ) via a pH\u2010induced disassembly\/reassembly method to obtain Ru(bpy)\u2010loaded nanoformulation (\n                    <jats:bold>Ru\u2013Aftn<\/jats:bold>\n                    ). This nanoformulation exhibits sustained release of the loaded complex over a period of 6 days with minimal burst release. Ru\u2013Aftn also displays prominent cytotoxicity with better selectivity than the non\u2010encapsulated Ru(bpy) complex against MCF\u20107 breast cancer cells. AO\/EB staining assay revealed that the non\u2010encapsulated complex induced late apoptosis before loading, whereas early apoptosis occurred after being loaded into Aftn. These results support that Aftn can act as a promising carrier for metallodrugs in modulating their molecular mechanism. Nevertheless, it fails to improve the antimicrobial activity of Ru(bpy) when tested against ancomycin\u2010resistant Enterococcus (\n                    <jats:bold>VRE<\/jats:bold>\n                    ) strains.\n                  <\/jats:p>","DOI":"10.1002\/asia.202500781","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:25:09Z","timestamp":1758536709000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Horse Spleen Apoferritin\u2010Encapsulated Organoruthenium Complex Bearing Pyrazolyl\u2013Pyridine Ligand for Cytotoxic and Antimicrobial Resistance Modulations"],"prefix":"10.1002","volume":"20","author":[{"given":"Arangasamy","family":"Mounica","sequence":"first","affiliation":[{"name":"Department of Chemistry SRM Institute of Science and Technology  Kattankulathur Chengalpattu Tamil Nadu 603203 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubramani","family":"Saveetha","sequence":"additional","affiliation":[{"name":"Department of Chemistry SRM Institute of Science and Technology  Kattankulathur Chengalpattu Tamil Nadu 603203 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arumugam","family":"Madan kumar","sequence":"additional","affiliation":[{"name":"Cancer Biology Lab, Molecular and Nanomedicine Research unit Sathyabama Institute of Science and Technology  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-3734","authenticated-orcid":false,"given":"Mani","family":"Ganeshpandian","sequence":"additional","affiliation":[{"name":"Department of Chemistry SRM Institute of Science and Technology  Kattankulathur Chengalpattu Tamil Nadu 603203 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.9734\/jpri\/2021\/v33i56A33889"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.9734\/jpri\/2022\/v34i46A36371"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.21635"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860151116349"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3599"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00261-6"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2018.4661"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/2211738507666190122111224"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2013.11.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","unstructured":"D.Singh R. 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